文章摘要
注意缺陷多动障碍儿童血清NT-3、FGF22水平及其诊断价值
投稿时间：2025-11-20  修订日期：2026-06-18
DOI：
中文关键词: 注意缺陷多动障碍  神经营养因子3  成纤维细胞生长因子22  诊断价值
英文关键词: Attention deficit hyperactivity disorder  Neurotrophin-3  fibroblast growth factor 22  Diagnostic value
基金项目:注意缺陷多动障碍；神经营养因子3；成纤维细胞生长因子22；诊断价值
作者单位邮编
田雪入* 江油市精神病医院 621700
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中文摘要:
      目的:探究注意缺陷多动障碍(ADHD)儿童血清神经营养因子3(NT-3)、成纤维细胞生长因子22(FGF22)水平及其诊断价值。方法:选择2022年5月~2025年5月在本院收治的132例ADHD儿童作为ADHD组。根据ADHD疾病严重程度分级标准分为轻中度组(82例)、重度组(50例)。另选取在本院同期体检的132例健康儿童作为Ctrl组。ELISA法检测血清NT-3、FGF22水平；Pearson分析血清NT-3、FGF22水平与CRT评分、PSQ评分的相关性；Logistic回归分析影响ADHD儿童病情严重程度的因素；ROC曲线分析血清NT-3、FGF22水平对ADHD及严重程度的诊断价值。结果:与Ctrl组相比,ADHD组血清NT-3、FGF22水平降低(P<0.05)。与轻中度组相比,重度组CRT评分、NT-3、FGF22水平降低,PSQ评分升高(P<0.05)。血清NT-3、FGF22水平分别与CRT评分呈正相关,与PSQ评分呈负相关(P<0.05)。CRT评分、PSQ评分、NT-3、FGF22水平是影响ADHD儿童病情严重程度的因素(P<0.05)。血清NT-3、FGF22水平单独与联合诊断ADHD的曲线下面积(AUC)分别为0.814、0.784、0.861,联合优于各自单独诊断,敏感度为93.18%,特异度为67.42%。血清NT-3、FGF22水平单独与联合诊断重度ADHD的AUC分别为0.871、0.828、0.914,联合优于各自单独诊断,敏感度为90.00%,特异度为78.26%。结论:ADHD患者血清NT-3、FGF22水平降低,二者联合对ADHD及重度ADHD诊断的良好效能。
英文摘要:
      Objective: To explore the levels of serum neurotrophin-3 (NT-3) and fibroblast growth factor 22 (FGF22) in children with attention deficit hyperactivity disorder (ADHD) and their diagnostic value. Methods: A total of 132 children with ADHD admitted to our hospital from May 2022 to May 2025 were considered as the ADHD group. Complying with the severity classification criteria of ADHD, they were assigned into the mild to moderate group (82 cases) and the severe group (50 cases). Another 132 healthy children who underwent physical examinations in our hospital were considered as the Ctrl group. ELISA was performed to detect the levels of serum NT-3 and FGF22. Pearson method was performed to explore the correlations between serum NT-3, FGF22 levels and CRT score, PSQ score. Logistic regression was performed to explore the factors influencing the severity of ADHD in children. In addition, ROC curve was used to explore the diagnostic value of serum NT-3 and FGF22 levels for ADHD and their severity. Results: Compared with the Ctrl group, the ADHD group had lower levels of serum NT-3 and FGF22 (P<0.05). Compared with the mild to moderate group, the severe group had lower CRT score, NT-3 and FGF22 levels, and a higher PSQ score (P<0.05). Serum NT-3 and FGF22 were positively correlated with the CRT score and negatively correlated with the PSQ score respectively (P<0.05). CRT score, PSQ score, NT-3 and FGF22 levels were factors affecting the severity of ADHD in children (P<0.05). The area under the curve (AUC) values of serum NT-3 and FGF22 levels alone and in combination for the diagnosis of ADHD were 0.814, 0.784, and 0.861, respectively. The combination was superior to the individual diagnosis, with a sensitivity of 93.18% and a specificity of 67.42%. The AUC values of serum NT-3 and FGF22 levels alone and in combination in the diagnosis of severe ADHD were 0.871, 0.828, and 0.914, respectively. The combination was superior to the individual diagnosis, with a sensitivity of 90.00% and a specificity of 78.26%. Conclusion: Serum NT-3 and FGF22 in patients with ADHD are decreased. The combination of the two has a good efficacy in the diagnosis of ADHD and severe ADHD.
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