文章摘要
血清VILIP-1、8-OHdG与帕金森病患者认知功能障碍的关系
投稿时间：2025-12-25  修订日期：2026-08-03
DOI：
中文关键词: 帕金森病  视锥蛋白样蛋白-1  8-羟基脱氧鸟苷  认知功能障碍  诊断
英文关键词: Parkinson"s disease  visinin-like protein 1  8-hydroxydeoxyguanosine  cognitive impairment  diagnosis
基金项目:齐齐哈尔医学科学院项目QMSI2023Z-15
作者单位邮编
隋丽娜* 哈尔滨市第一专科医院 150056
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中文摘要:
      目的:探讨血清视锥蛋白样蛋白-1(VILIP-1)、8-羟基脱氧鸟苷(8-OHdG)与帕金森病(PD)患者认知功能障碍的关系。方法:选取2023年1月~2025年3月期间在本院收治的127例PD患者为研究对象(PD组),按照H-Y分级将PD患者分为早期PD组(1~2.5级,76例)和中晚期PD组(3~5级,51例),根据蒙特利尔认知评估量表(MoCA)将PD患者分为认知正常组(59例)和认知障碍组(68例)；同期选取93例诊断为其他神经退行性疾病(如阿尔茨海默病、路易体痴呆等),但不符合帕金森病诊断标准的住院患者,作为对照组。ELISA法检测血清VILIP-1、8-OHdG水平；Pearson法分析PD患者血清VILIP-1、8-OHdG水平与MoCA评分的相关性；多因素Logistic回归分析影响PD患者发生认知功能障碍的相关因素；ROC曲线分析血清VILIP-1、8-OHdG水平对PD患者发生认知功能障碍的诊断价值。结果:PD组血清VILIP-1、8-OHdG水平较对照组显著升高(t=14.518、22.515,P＜0.05)；中晚期PD组患者血清VILIP-1、8-OHdG水平较早期PD组患者显著升高(t=11.035、7.301,P＜0.05)；认知障碍组患者年龄、PD病程、MoCA评分以及血清VILIP-1、8-OHdG水平较认知正常组患者均升高(t=2.821、9.641、20.408、7.807、8.556,P＜0.05)；PD患者血清VILIP-1、8-OHdG水平与MoCA评分均呈负相关(r=-0.616、-0.450,P＜0.05)；年龄偏大(OR=2.317)、病程较长(OR=2.673)、VILIP-1(OR=3.548)、8-OHdG(OR=3.291)水平升高均是影响PD患者发生认知功能障碍的危险因素(P＜0.05)；血清VILIP-1、8-OHdG联合诊断PD患者发生认知功能障碍的AUC为0.951,其诊断价值优于各自单独诊断(Z二者联合-VILIP-1=2.702、Z二者联合-8-OHdG=3.130,P＜0.05)。结论:PD患者血清VILIP-1、8-OHdG水平均显著升高,二者与认知功能障碍的发生密切相关,且联合检测对PD患者认知功能障碍的鉴别效能较高。
英文摘要:
      Objective: Investigating the relationship between serum visinin-like protein-1 (VILIP-1) and 8-hydroxydeoxyguanosine (8-OHdG) for cognitive impairment in Parkinson"s disease (PD) patients. Methods: From January 2023 to March 2025, 127 PD patients admitted to our hospital were enrolled as the study subjects (PD group). PD patients were classified into early stage PD group (grades 1-2.5, 76 cases) and middle to late stage PD group (grades 3-5, 51 cases) complying with H-Y grading. PD patients were classified into cognitive normal group (59 cases) and cognitive impairment group (68 cases) complying with the Montreal Cognitive Assessment Scale (MoCA). Another 93 healthy volunteers who came to our hospital for physical examination were served as the control group. ELISA method was performed to detect serum VILIP-1 and 8-OHdG. Pearson method was performed to discuss the correlation between serum VILIP-1, 8-OHdG and MoCA score in PD patients. Multivariate logistic regression was performed to discuss the relevant factors affecting cognitive impairment in PD patients. ROC curve was used to discuss the diagnostic value of serum VILIP-1 and 8-OHdG for cognitive impairment in PD patients. Results: The PD group had clearly higher serum VILIP-1 and 8-OHdG than the control group (t=14.518, 22.515, P<0.05). The middle to late stage PD group had clearly higher serum VILIP-1 and 8-OHdG than the early stage PD group (t=11.035, 7.301, P<0.05). Patients in the cognitive impairment group had clearly larger age, PD duration, MoCA score, and serum VILIP-1 and 8-OHdG levels than patients in the cognitively normal group (t=2.821, 9.641, 20.408, 7.807, 8.556, P<0.05). The serum VILIP-1 and 8-OHdG in PD patients were negatively correlated with MoCA scores (r=-0.616, -0.450, P<0.05). Older age (OR=2.317), longer disease duration (OR=2.673), elevated VILIP-1 (OR=3.548), and elevated 8-OHdG (OR=3.291) were all risk factors for cognitive impairment in PD patients (P<0.05). The joint of serum VILIP-1 and 8-OHdG had an AUC of 0.951 for the diagnosis of cognitive impairment in PD patients, and its diagnostic value was better than that of each individual diagnosis (Z joint-VILIP-1=2.702, Z joint-8-OHdG=3.130, P<0.05). Conclusion: Serum VILIP-1 and 8-OHdG in PD patients are clearly elevated. Both are closely related to the occurrence of cognitive impairment. and their combined detection demonstrated high discriminatory efficacy for identifying cognitive dysfunction in PD patients.
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