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| 灵活低剂量GnRH拮抗剂方案对多囊卵巢综合征人群行新鲜胚胎移植的妊娠结局影响 |
| The impact of flexible low-dose GnRH antagonist protocols on pregnancy outcomes in fresh embryo transfer among women with polycystic ovary syndrome |
| 投稿时间：2025-09-07 |
| DOI：10.3969/j.issn.1000-0399.2026.08.006 |
| 中文关键词: 灵活低剂量促性腺激素释放激素拮抗剂方案 新鲜周期 体外受精或卵胞质内单精子注射-胚胎移植 妊娠结局 多囊卵巢综合征 |
| 英文关键词: Flexible low-dose GnRH antagonist protocol Fresh cycle IVF/ICSI-ET Pregnancy outcome PCOS |
| 基金项目:山东省自然科学基金(编号:ZR2025MS1519);山东省高校科技计划项目(编号:J17KA254);山东第二医科大学研究生科研基金(编号:2025YJSCX017);潍坊市科技发展计划项目(编号:2024YX046) |
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| 中文摘要: |
| 目的 比较促性腺激素释放激素（GnRH）拮抗剂灵活低剂量方案和常规剂量方案对多囊卵巢综合征人群行新鲜胚胎移植临床妊娠结局的影响。方法 回顾性分析2020年3月至2021年9月在潍坊医学院附属医院生殖中心接受GnRH拮抗剂方案行新鲜胚胎移植的241例多囊卵巢综合征（PCOS）患者的临床资料，根据GnRH拮抗剂使用剂量的不同将患者分为灵活低剂量拮抗剂组（试验组，120例）和常规剂量拮抗剂组（对照组，121例）。分别比较两组患者的GnRH拮抗剂总剂量、黄体生成素（LH）激增率、优胚率、临床妊娠率的差异。结果 试验组GnRH拮抗剂使用量低于对照组，差异具有统计学意义（P<0.05）。试验组与对照组的LH激增率、优胚率、临床妊娠率比较，差异无统计学意义（P>0.05）。结论 在PCOS患者拮抗剂体外受精或卵胞质内单精子注射-胚胎移植（IVF/ICSI-ET）治疗方案中，灵活低剂量GnRH拮抗剂在IVF/ICSI-ET的新鲜胚胎移植周期中可获得与常规剂量拮抗剂方案相似的临床结局。 |
| 英文摘要: |
| Objective To compare the effects of flexible low-dose regimens versus conventional dose regimens of gonadotropin-releasing hormone(GnRH) antagonists on clinical pregnancy outcomes in fresh embryo transfer(FET) among patients with polycystic ovary syndrome(PCOS). Methods A retrospective analysis was conducted on the clinical data of 241 PCOS patients who underwent GnRH antagonist regimens for FET at the Reproductive Center of Weifang Medical University Affiliated Hospital from March 2020 to September 2021. Patients were divided into a flexible low-dose antagonist group(trial group, n=120) and a conventional dose antagonist group(control group, n=121) based on GnRH antagonist dosage. Differences in total GnRH antagonist dosage, luteinizing hormone(LH) surge rate, optimal embryo rate, and clinical pregnancy rate were compared between the two groups. Results The GnRH antagonist dosage in the trial group was significantly lower than that in the control group(P<0.05). No statistically significant differences were observed in LH surge rate, optimal embryo rate, or clinical pregnancy rate between the two groups(P>0.05). Conclusion In FET cycles for PCOS patients undergoing antagonist-based in vitro fertilization or intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET), flexible low-dose GnRH antagonists can achieve clinical outcomes comparable to conventional dose regimens during FET/ICSI-ET procedures. |
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