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| 血清KL-6水平与常见结缔组织病并发肺间质病变的关系研究 |
| Relationship between serum KL-6 level and interstitial lung disease in common connective tissue diseases |
| 投稿时间：2022-05-26 |
| DOI：10.3969/j.issn.1000-0399.2023.01.006 |
| 中文关键词: 结缔组织病 肺间质病变 涎液化糖链抗原 高分辨CT 肺部感染 |
| 英文关键词: Connective tissue disease Interstitial lung disease Krebs von den Lungen-6 High resolution CT Lung infection |
| 基金项目:蚌埠医学院2021年度研究生科研创新计划项目(编号:Byycxz21063),2021年度蚌埠医学院第一附属医院高新技术项目(编号:2021193) |
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| 中文摘要: |
| 目的 了解血清涎液化糖链抗原(KL-6)在常见结缔组织病(CTD)并发肺间质病变(ILD)患者中的表达水平及其临床意义。方法 选取2021年4～11月蚌埠医学院第一附属医院收治的187例CTD患者为研究对象,按照结缔组织病有无肺间质病变分为结缔组织病并发肺间质病变(CTD-ILD)组116例,结缔组织病无肺间质病变(CTD-NILD)组71例;选取41例同期本院体检健康者为对照组。在CTD-ILD组中,根据肺高分辨CT(HRCT)表现分为急性组和慢性组;根据HRCT显示的ILD累及范围进行分级(1级,累及范围≤25%;2级,25%<累及范围≤50%;3级,50%<累及范围≤75%;4级,75%<累及范围≤100%);随后根据CTD-ILD患者是否合并有肺部感染分为有肺部感染组和无肺部感染组。采用乳胶凝集法测定血清KL-6水平,比较不同分组血清KL-6水平差异。[结果 CTD-ILD组血清KL-6水平高于CTD-NILD组和对照组,差异有统计学意义(P<0.05)。CTD-ILD患者血清KL-6水平在急性组高于慢性组(P<0.05),在有肺部感染组和无肺部感染组差异无统计学意义(P>0.05);HRCT示CTD患者ILD累及范围与血清KL-6水平成正相关(r=0.681,P<0.05),且ILD累及范围是血清KL-6水平的主要影响因素。ROC曲线显示:CTD-ILD患者血清KL-6截断值为207.8 U/mL,灵敏度为56.0%,特异度为98.2%。结论 检测血清KL-6水平在临床上诊断CTD-ILD及评估其严重程度有一定的应用价值。 |
| 英文摘要: |
| Objective To investigate the expression level and clinical significance of Krebsvonden Lungen-6 (KL-6) in patients with common connective tissue disease (CTD) complicated with interstitial lung disease (ILD). Methods Onehundredand eighty-seven patients with CTD admitted to the First Affiliated Hospital of Bengbu Medical College from April to November 2021 were selected and divided into connective tissue disease with interstitial lung disease (CTD-ILD) group (116 cases) and connective tissue disease without interstitial lung disease (CTD-NILD) group (71 cases) according to whether connective tissue disease had interstitial lung disease or not. A total of 41 healthy subjects were selected as the control group. The CTD-ILD group was divided into acute group and chronic group according to lung high resolution CT (HRCT) findings. ILD was graded according to the extent of HRCT (grade 1, involvement range ≤25%,grade 2, 25%Results Serum KL-6 level in CTD-ILD group was higher than that in CTD-NILD group and control group, and the difference was statistically significant (P<0.05). Serum KL-6 level in SS patients complicated with ILD was higher than that in SLE and RA patients (P<0.05). Serum KL-6 level of CTD-ILD patients in the acute group was higher than that in the chronic group (P<0.05), and there was no significant difference between the pulmonary infection group and the non-pulmonary infection group (P>0.05).HRCT showed that the extent of ILD involvement was positively correlated with serum KL-6 level in CTD patients (r=0.681,P<0.05), and the extent of ILD involvement was a risk factor affecting serum KL-6 level. The cut-off value of serum KL-6 in CTD-ILD patients was 207.8 U/mL.Conclusion Thedetection of serum KL-6 level has certain application value in the diagnosis and evaluation of CTD-ILD. |
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