| Objective To investigate the clinical efficacy of Abersip's combination of full retinal laser photocoagulation to treat ischemic retinal central venous obstruction (CRVO) with macular edema (ME) and its effect on patients' retinal blood flow and endothelial endothelial growth factor (VEGF), matrix cell derivative factor-1 (SDF-1). Methods The 96 patients with ISCHEMIC CRVO companion ME admitted to our hospital from March 2018 to December 2020 were selected and divided into two groups using random numerical table method, with 48 cases in each. The observation group was given Abersip joint full retinal laser photocoagulation therapy, and the control group simply implemented full retinal laser photocoagulation therapy. After 12 weeks of continuous treatment, the two groups was compared in terms of of optimal corrective vision (BCVA) (the minimum resolution angle log MAR), the macular center concave thickness (CMT), the retinal blood flow parameters retinal shallow capillary (SCP) blood flow density, macular center concave no blood vessel area (FAZ) and room water VEGF, SDF-1 level. The treatment effect of the two groups were evaluated according to the improvement of BCVA, bleeding absorption, the disappearance of fluorescein leakage in macular area, no perfusion area, ME and the recovery of CMT. Adverse reactions in both groups, including local subconjunctival hemorrhage and transient intraocular pressure increase, were recorded. Results The total effective rate of observation group was 93.75%, significantly higher than that of control group (75.00%, P<0.05). There was no significant difference in logMAR BCVA and CMT between the two groups before treatment (P>0.05). The difference in logMAR BCVA and CMT before and after treatment in the observation group was higher than that in the control group, with statistical significance (P<0.05). There were no significant differences in SCP blood flow density and FAZ area between the two groups before treatment (P>0.05). The difference in SCP blood density of the observation group before and after treatment was higher than that of the control group, with statistical significance (P<0.05). There was no significant difference in FAZ area between the two groups before and after treatment (P>0.05). There was no significant difference in VEGF and SDF-1 content in aqueous humor between the two groups before treatment (P>0.05). The differences in VEGF and SDF-1 in aqueous humor of the observation group before and after treatment were higher than those of the control group, with statistical significance (P<0.05). Conclusions The combination of Abersip's full retinal laser photocoagulation treatment can improve the clinical efficacy of ISCHEMIC CRVO companion ME, and the patients' vision recovery is good, ME recedes obviously, and its effect may be related to the lowering of the expression level of VEGF and SDF-1. |
