文章摘要
血清PTTG1 TK1 LncRNA水平在原发性喉癌临床诊断及疗效预测中的价值
Value of levels of serum PTTG1 TK1 and LncRNA in clinical diagnosis and efficacy prediction of primary laryngeal cancer
投稿时间：2022-06-20  
DOI：10.3969/j.issn.1000-0399.2023.03.008
中文关键词: 原发性喉癌  垂体瘤转化基因1  胸苷激酶1  长链非编码RNA H19
英文关键词: Primary laryngeal cancer  Pituitary tumor-transforming gene 1  Thymidine kinase 1  Long non-coding RNA H19
基金项目:
作者单位
杨荣松 473000 河南南阳 河南省南阳市中心医院耳鼻喉科 
杨琛 473000 河南南阳 河南省南阳市中心医院耳鼻喉科 
魏璐璐 473000 河南南阳 河南省南阳市中心医院耳鼻喉科 
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中文摘要:
      目的 探究血清垂体瘤转化基因1（PTTG1）、胸苷激酶1（TK1）、长链非编码RNA H19（lncRNA H19）在原发性喉癌临床诊断及疗效预测中的应用价值。方法 选取2016年1月至2021年5月于河南省南阳市中心医院收治的143例疑似原发性喉癌患者为研究对象，根据病理诊断结果，将原发性喉癌的患者设为观察组（n=61），将良性病变的患者设为对照组（n=82）。比较两组患者血清PTTG1、TK1、LncRNA H19水平差异，使用受试者特征（ROC）曲线分析血清PTTG1、TK1、LncRNA H19水平对原发性喉癌的诊断效能。使用单因素方差分析观察组不同原发性喉癌分期患者血清PTTG1、TK1、LncRNA H19水平的差异，比较不同疗效患者血清PTTG1、TK1、LncRNA H19水平差异，使用ROC曲线探究血清PTTG1、TK1、LncRNA H19水平对患者疗效的预测价值。结果 观察组血清PTTG1、TK1、LncRNA H19表达水平均高于对照组（P均<0.05）；ROC曲线结果显示，血清PTTG1、TK1、LncRNA H19表达水平对原发性喉癌患者的诊断效能均较高（AUC=0.897、0.869、0.968，P均<0.05）；经单因素方差分析，不同分期的原发性喉癌患者之间，血清PTTG1、TK1、LncRNA H19表达水平均差异有统计学意义（P<0.05）；有效组患者血清PTTG1、TK1、LncRNA H19表达水平均低于无效组（P均<0.05）；ROC曲线结果显示，血清PTTG1、TK1、LncRNA H19表达水平对原发性喉癌患者疗效的预测效能均较高（AUC=0.855、0.785、0.678，P均<0.05）。结论 血清PTTG1、TK1、LncRNA H19用于诊断原发性喉癌，其预测分期和疗效价值均较高。
英文摘要:
      Objective To explore the application value of serum pituitary tumor-transforming gene 1 (PTTG1), thymidine kinase 1 (TK1) and long non-coding RNA H19 (lncRNA H19) in the clinical diagnosis of patients with primary laryngeal cancer and prediction of efficacy. Methods A total of 143 patients with suspected primary laryngeal cancer admitted to Nanyang Central Hospital, Henan Province between January 2016 and May 2021 were enrolled as the research subjects. According to the pathological diagnosis results, the patients with primary laryngeal cancer were set as observation group (n=61), and those with benign lesions were served as control group (n=82). The differences in levels of serum PTTG1, TK1 and LncRNA H19 of the two groups of patients were compared, and receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficiency of levels of serum PTTG1, TK1 and LncRNA H19 on primary laryngeal cancer. One-way analysis of variance was applied to explore the relationship between serum PTTG1, TK1 and LncRNA H19 levels and primary laryngeal cancer staging in the observation group. The differences in levels of serum PTTG1, TK1 and LncRNA H19 were compared among patients with different efficacy status, and ROC curve was adopted to explore the predictive value of serum PTTG1, TK1 and LncRNA H19 in efficacy of patients. Results The expression levels of serum PTTG1, TK1 and LncRNA H19 in the observation group were higher than those in the control group (all P<0.05). ROC curve results showed that the expression levels of serum PTTG1, TK1 and LncRNA H19 had high diagnostic efficiency in patients with primary laryngeal cancer (AUC=0.897, 0.896, 0, 968, all P<0.05). One-way analysis of variance showed that the expression levels of serum PTTG1, TK1 and LncRNA H19 were significantly different among patients with different stages of primary laryngeal cancer (P<0.05). The expression levels of serum PTTG1, TK1 and LncRNA H19 of patients in the effective group were lower than those in the ineffective group (all P<0.05). ROC curve showed that the expression levels of serum PTTG1, TK1 and LncRNA H19 had high predictive efficiency in patients with primary laryngeal cancer (AUC=0.855, 0.785, 0.678, all P<0.05). Conclusions Serum PTTG1, TK1 and LncRNA H19 are of high value in the diagnosis of primary laryngeal cancer and predicting the efficacy.
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