文章摘要
PNI指数对食管癌患者预后疗效的评估价值分析
Analysis of evaluated value of PNI index in the prognosis efficacy of patientswith esophageal cancer
投稿时间：2019-01-18  修订日期：2019-03-26
DOI：
中文关键词: 预后营养指数  食管癌  预后  生存率
英文关键词: Prognostic nutritional index  Esophageal cancer  Prognosis  Survival rate
基金项目:
作者单位邮编
李东峰* 河南省荣军医院 453000
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中文摘要:
      目的 探讨预后营养指数(PNI)对食管癌患者预后疗效的评估价值。方法 回顾性分析2013年6月~2015年6月我院接诊的125例食管癌患者的临床资料,以45为临界值,将患者分为高PNI组与低PNI组,比较两组患者年龄、性别、吸烟史、饮酒史、肿瘤直径、TNM分期、淋巴结转移、术后排气时间、组织分化程度、肿瘤位置、脉管瘤栓、术后排便时间；随访3年,采用Kaplan-Meier法绘制生存曲线,比较高PNI组与低PNI组的生存率,并进行影响患者预后的单因素和多因素分析。结果 高PNI组与低PNI组患者年龄、肿瘤直径、TNM分期、淋巴结转移、术后排气时间比较,差异有统计学意义(P<0.05)；两组患者性别、吸烟、饮酒、组织分化程度、肿瘤位置、脉管瘤栓、术后排便时间比较,差异无统计学意义(P>0.05)；125例食管癌患者术后3年的总体生存率为46.40%(58/125),高PNI组的3年总生存率为81.13%(43/53),明显高于低PNI组的20.83%(15/72)(P<0.05)；单因素分析显示,肿瘤直径、TNM分期、淋巴结转移、PNI指数、复发或转移是影响食管癌患者3年生存率的显著因素(P<0.05)；多因素logistic回归分析显示,肿瘤直径、TNM分期、淋巴结转移、低PNI指数、复发或转移是影响食管癌患者预后的独立危险因素(P<0.05)。结论 PNI指数能较好地反映食管癌患者的手术风险及营养状态,在评估食管癌患者预后疗效中临床价值较高。
英文摘要:
      Objective To explore the evaluated value of prognostic nutritional index (PNI) in the prognosis efficacy of patients with esophageal cancer. Methods The clinical data of 125 patients with esophageal cancer admitted to our hospital from June 2013 to June 2015 were retrospectively analyzed. The patients were divided into high PNI group and low PNI group with 45 as the critical value. The age, gender, smoking or not, drinking or not, tumor diameter, TNM stage, lymph node metastasis, postoperative exhaust time, tissue differentiation degree, tumor location, vascular tumor thrombus and postoperative defecation time were compared between the two groups. At 3 years of follow-up, Kaplan-Meier method was used to draw survival curves, and the survival rate was compared between high PNI group and low PNI group, and univariate analysis and multivariate analysis that affected the prognosis of patients were performed. Results There were significant differences in the age, tumor diameter, TNM stage, lymph node metastasis and postoperative exhaust time between high PNI group and low PNI group (P<0.05). There were no significant differences in the gender, smoking, drinking, tissue differentiation degree, tumor location, vascular tumor thrombus and postoperative defecation time between the two groups (P>0.05). The overall survival rate at 3 years after operation of 125 patients with esophageal cancer was 46.40% (58/125), and the 3-year overall survival rate in high PNI group was significantly higher than that in low PNI group [81.13% (43/53) vs 20.83% (15/72)]. Univariate analysis showed tumor diameter, TNM stage, lymph node metastasis, PNI index and recurrence or metastasis were significant factors affecting the 3-year survival rate of patients with esophageal cancer (P<0.05). Multivariate logistic regression analysis showed that tumor diameter, TNM stage, lymph node metastasis, low PNI index and recurrence or metastasis were independent risk factors for prognosis in patients with esophageal cancer (P<0.05). Conclusions PNI index can better reflect the surgical risk and nutritional status of patients with esophageal cancer, and has a higher clinical value in evaluating the prognosis efficacy of patients with esophageal cancer.
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