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| IABP辅助PCI治疗高危急性冠脉综合征的效果评估 |
| Efficacy evaluation of adjunctive IABP for high-risk ACS patients undergoing PCI |
| 投稿时间：2014-09-15 修订日期：2015-02-28 |
| DOI：10.3969/j.issn.1000-0399.2015.06.020 |
| 中文关键词: 主动脉内球囊反搏 急性冠脉综合征 N末端B型利钠肽原 超敏C反应蛋白 左心室射血分数 |
| 英文关键词: Intra-aotric balloon pump Acute coronary syndrome N-terminal pro-B-type natriuretic peptide Hypersensitive C-reactive protein Left ventricular ejection fraction |
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| 中文摘要: |
| 目的 评价主动脉内球囊反搏术(IABP)辅助经皮冠状动脉介入(PCI)治疗高危急性冠脉综合征(ACS)患者的效果。方法 选取95例ACS合并血流动力学不稳定或心源性休克的高危患者并分为两组, 50例患者PCI前24 h内进行IABP治疗(IABP+PCI组), 45例直接PCI(PCI组)。在入院及PCI术后第5天分别检测N末端B型利钠肽原(NT-proBNP)和超敏C反应蛋白(hs-CRP)水平;入院时及出院后4周心脏彩超测定左心室射血分数(LVEF)。结果 治疗前两组收缩压均偏低, 两组差异无统计学意义(P>0.05)。治疗后, IABP+PCI组血压较PCI组血压明显升高(P<0.05);同时IABP+PCI组病死率有所下降(P<0.05), 住院天数减少 (P<0.05)。两组治疗前的血浆NT-proBNP 和 hs-CRP差异无统计学意义 (P>0.05), 治疗后IABP+PCI组血浆NT-proBNP 和 hs-CRP水平较PCI组明显下降(P<0.05), LVEF明显提高(P<0.05)。结论 IABP辅助PCI治疗高危ACS患者, 在一定程度上改善了血流动力学, 并使住院天数和短期病死率有所下降, 同时降低了血浆NT-proBNP 和 hs-CRP水平, 提高了LVEF。 |
| 英文摘要: |
| Objective To evaluate the efficacy of intra-aortic balloon pump(IABP) as an adjunct to percutaneous coronary intervention(PCI) for high-risk acute coronary syndromes(ACS) patients. Methods Ninety five high-risk ACS patients with unstable hemodynamic or cardiogenic shock who underwent PCI were divided into two groups, 50 patients were treated with IABP within 24 hours before PCI (IABP+PCI group), and 45 patients with PCI only (PCI group). Plasma NT-proBNP and hs-CRP were measured on the first day during hospitalization and fifth day after PCI. Left ventricular ejection fraction(LVEF) was measured by echocardiography on the first day during hospitalization, and 4 weeks after discharge. Results SBP of the two groups was low before the treatment, with no significant difference between the two groups(P>0.05). After the treatment, SBP was significantly higher in the patients underwent PCI with IABP support compared with control group(P<0.05). Moreover, undergoing PCI with IABP support could decrease the short-time mortality(P<0.05), and decrease the hospitalization days (P<0.05). NT-proBNP and hs-CRP of the two groups were increased at the beginning of the treatment, but there was no significant difference between the two groups (P>0.05). After the treatment, NT-proBNP and Hs-CRP decreased and LVEF increased more significantly in IABP group (P<0.05). Conclusion For high-risk patients with unstable hemodynamics or cardiogenic shock, PCI with IABP support could improve hemodynamics to a certain extent and decrease hospitalization days and the short -time mortality; PCI with IABP support could also decrease plasma NT-proBNP, hs-CRP, and LVEF. |
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