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| 急性脑梗死患者血浆同型半胱氨酸水平高血压与脑微出血的相关性分析 |
| Correlation between plasma homocysteine level hypertension and cerebral microbleeds in patients with acute cerebral infarction |
| 投稿时间：2014-08-05 修订日期：2015-01-25 |
| DOI：10.3969/j.issn.1000-0399.2015.06.026 |
| 中文关键词: 同型半胱氨酸 脑微出血 高血压 危险因素 卒中 |
| 英文关键词: Homocysteine Cerebral microbleeds Hypertension Risk factors Stroke |
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| 中文摘要: |
| 目的 探讨急性脑梗死患者血浆同型半胱氨酸(Hcy)水平、高血压与脑微出血(CMB)的关系。方法 选择铜陵市人民医院神经内科2011年1月至2012年1月收治的急性脑梗死患者74例, 对其临床及影像学资料进行回顾性分析。根据是否存在CMB分为CMB组和无CMB组。记录两组患者血压、血脂、血糖、血浆Hcy水平等情况, 并探讨CMB的危险因素。结果 74例急性脑梗死患者中, 男性51例, 女性23例, 平均(66.22±8.96)岁。logistic回归分析显示, CMB的发生与高血压密切相关(OR=4.67, 95% CI:1.23～17.65, P=0.02), 与血浆Hcy水平无明显相关(OR=1.01, 95% CI:0.97～1.06, P=0.38)。结论 CMB与血浆Hcy水平增高无关, 与高血压显著相关, 高血压可能为其独立危险因素。 |
| 英文摘要: |
| Objective To investigate the correlation between plasma homocysteine(Hcy) level, hypertension and cerebral microbleeds(CMBs) in patients with acute cerebral infarction. Methods The clinical and imaging data of 74 patients with acute cerebral infarction who had been admitted in this hospital from January 2011 to January 2012 were analyzed retrospectively. According to the existence of cerebral microbleeds, the patients were divided into two groups, namely the CMB group and the non-CMB group. Blood pressure, blood lipids, blood glucose, and plasma homocysteine were recorded in the two groups of patients, and the risk factors for cerebral microbleeds in acute cerebral infarction were explored. Results A total of 74 patients with acute cerebral infarction were enrolled, 23 of them were females and 51 were males (mean age 66.22±8.96 years). Multivariate logistic regression analysis showed that cerebral microbleeds was associated closely with hypertension(OR=4.67, 95% CI:1.2～17.65, P=0.02), but plasma Hcy level was not related to CMBs(OR=1.01, 95% CI: 0.97～1.06, P=0.38). Conclusion The level of elevated plasma Hcy in patients with acute cerebral infarction is unrelated to CMBs. Hypertension is significantly associated with CMBs, which might be the independent risk factor for CMBs. |
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