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| 血清G-17 PG-Ⅰ PG-Ⅱ水平与幽门螺杆菌感染的相关性分析 |
| The relationship between change of serum G-17, PG-Ⅰ, PG-Ⅱ and Helicobacter pylori infection |
| 投稿时间：2015-02-17 修订日期：2015-04-28 |
| DOI：10.3969/j.issn.1000-0399.2015.08.014 |
| 中文关键词: 胃泌素-17 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 幽门螺杆菌 |
| 英文关键词: Gastrin-17 Pepsinogen I Pepsinogen II Helicobacter pylori |
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| 中文摘要: |
| 目的 检测幽门螺杆菌(HP)感染患者血清中胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PG-Ⅰ)和胃蛋白酶原Ⅱ(PG-Ⅱ)的含量,探讨其与HP感染发生的相关性。方法 用ELISA法分别定量检测HP感染阳性组和HP感染阴性组患者血清中G-17、PG-Ⅰ和PG-Ⅱ的含量。结果 HP感染阳性组患者G-17、PG-Ⅱ和PG-Ⅰ/PG-Ⅱ的阳性检出量明显高于阴性组,差异有统计学意义(P <0.05),PG-Ⅰ在该两组之间的差异无统计学意义(P >0.05)。结论 G-17和PG-Ⅱ水平与HP感染有关联,可为HP感染或既往感染的诊断提供参考依据。 |
| 英文摘要: |
| Objective To detect the levels of gastrin-17 (G-17), pepsinogen I (PG-Ⅰ) and pepsinogen Ⅱ (PG-Ⅱ) in serum of patients with Helicobacter pylori infection, and to evaluate the relationship between the occurrence of Helicobacter pylori infection and serum levels. Methods Serum was collected from cases of 41 male and 44 female with positive Helicobacter pylori, and 44 male and 41 female with negative Helicobacter pylori. Serum levels of G-17, PG-Ⅰ and PG-Ⅱ were quantitatively detected by ELISA. Results The serum levels of G-17, PG-Ⅱ and PG-Ⅰ/PG-Ⅱ in Hp positive group were higher than those in Hp negative group, with significant differences in content in serum of two groups(P <0.05); in each group of PG- I there was no significant statistically significant difference (P >0.05). Conclusion Serum levels of G-17 and PG-Ⅱ levels are associated with Helicobacter pylori infection, which can be used as the relevant factors to provide reference basis for diagnosis of Helicobacter pylori infection or previous infection. |
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