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| 某院大肠埃希菌分布及耐药性分析 |
| Distribution of Escherichia coli and analysis of its drug resistance in a hospital |
| 投稿时间：2015-03-30 修订日期：2015-05-27 |
| DOI：10.3969/j.issn.1000-0399.2015.09.009 |
| 中文关键词: 大肠埃希菌 耐药率 超广谱β-内酰胺酶 抗菌药物 分布 |
| 英文关键词: Escherichia coli Drug resistance Extended-spectrum β-lactamases Antibiotics Distribution |
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| 中文摘要: |
| 目的 了解某院大肠埃希菌的分布特点及其耐药性,指导临床合理应用抗菌药物。方法 对766株大肠埃希菌的分布及耐药率进行回顾性分析。采用法国生物梅里埃公司全自动细菌鉴定仪 VITEK2 compact进行菌株鉴定,采用K-B法进行药敏试验,按美国临床实验室标准化委员会2014年标准判读结果。结果 766株大肠埃希菌主要分离自尿液和痰液标本,分别占52.87%和13.84%;其中鉴定出产超广谱β-内酰胺酶(ESBLs)大肠埃希菌366 株,占大肠埃希菌总数的47.78%。产ESBLs大肠埃希菌对常用抗菌药物的耐药率明显高于非产ESBLs大肠埃希菌(P<0.05)。结论 大肠埃希菌是泌尿道和呼吸道感染的常见病原菌,产ESBLs大肠埃希菌的耐药率高,临床上应根据药敏合理使用抗菌药物。 |
| 英文摘要: |
| Objective To study the distribution and its drug resistance of Escherichia coli in a hospital in order to introduce a reasonable clinical use of antibiotics. Methods We retrospectively analyzed the distribution and drug resistance rates of 766 strains of clinical Escherichia coli collected in the hospital, made the bacteria identifications by BioMerieux automatic bacteria identification analyzer(VITEK2 compact) and adopted Kirby-Bauer method for the drug-sensitivity tests. The results were determined according to the standard of Clinical and Laboratory Standards Institute (CLSI) issued in 2014. Results It was found that 766 strains of Escherichia coli were mainly isolated from urine (52.87%) and sputum (13.84%) specimens. There were 366 strains (47.78%) of Escherichia coli producing extended-spectrum β-lactamases (ESBLs). The drug resistance rates of Escherichia coli result in ESBLs to the common antibiotics were significantly higher than those of the non-ESBLs-producing Escherichia coli (P<0.05). Conclusion Escherichia coli is a type of common pathogen leading to urinary tract and respiratory tract infections. It is necessary to strengthen the reasonable clinical use of antibiotics in accordance with susceptibility testing because of the higher drug resistance rate of the ESBLs-producing Escherichia coli. |
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