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| 降钙素原抗凝血酶Ⅲ和D-二聚体在新生儿重症肺炎诊治中的价值 |
| The diagnostic value of procalcitionin, antithrombin Ⅲ and D-dimer in neonates with severe pneumonia |
| 投稿时间：2015-04-29 修订日期：2015-06-27 |
| DOI：10.3969/j.issn.1000-0399.2015.010.012 |
| 中文关键词: 重症肺炎,新生儿 降钙素原 抗凝血酶Ⅲ D-二聚体 |
| 英文关键词: Severe pneumonia, neonates Procalcitionin Antithrombin Ⅲ D-dimer |
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| 中文摘要: |
| 目的 探讨降钙素原、抗凝血酶Ⅲ和D-二聚体在新生儿重症肺炎诊治中的价值。方法 选取新生儿普通肺炎97例、重症肺炎43例及健康新生儿70例为研究对象。重症肺炎组患儿,按照外周血PCT水平分为PCT<2.00 ng/mL组和PCT≥2.00 ng/mL组。对全部新生儿采集静脉血分别测定血小板 (PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D‐二聚体(DD)和抗凝血酶Ⅲ(AT-Ⅲ)。结果 与健康新生儿组比较,普通肺炎组、重症肺炎组TT 、PT、APTT延长(P<0.05),PCT、DD、FIB水平升高(P<0.05),AT-Ⅲ和PLT水平降低(P<0.05)。 与普通肺炎组比较,重症肺炎组PCT、AT-Ⅲ和PLT水平降低(P<0.05),DD、FIB水平升高(P<0.05),两组PT、APTT、TT比较差异无统计学意义(P>0.05)。与PCT<2.00 ng/mL组比较,PCT≥2.00 ng/mL组的患儿DIC的发生率高(32.0% vs 11.1%),ATⅢ活性降低,PLT水平降低,而DD的水平升高,差异均有统计学意义(P<0.05)。结论 降钙素原、抗凝血酶Ⅲ和D-二聚体在新生儿重症肺炎诊治中具有重要的价值。 |
| 英文摘要: |
| Objective To evaluate the diagnosis of procalcitionin, antithrombin Ⅲand D-dimer in neonates with severe pneumonia. Methods The data of 210 neonates hospitalized in our hospital, including 97 neonates with common pneumonia, 43 neonates with severe pneumonia, and 70 healthy neonates, during 2012 and 2014 were analyzed retrospectively. The platelets (PLT) count, part of the activation thromoplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), antithrombin Ⅲ (AT-Ⅲ), D-dimer (DD)and procalcitionin (PCT) in the blood were tested within 24 hours after admission. Results PLT and AT-Ⅲ of other groups were significantly lower than those of group of healthy neonates(P<0.05), while APTT, PT, TT, DD, FIB and PCT significantly rose. However, the difference in PT, APTT, TT and FIB were not significant (P>0.05) in common pneumonia and severe pneumonia groups. The incidence of disseminated intravascular coagulation (DIC) in PCT≥2.00 ng/mL group was significantly higher than that in PCT<2.00 ng/mL group. Compared with PCT<2.00 ng/mL group,PLT and AT-Ⅲ were significantly lower (P<0.05), and DD and FIB were significantly increase(P<0.05) in PCT≥2.00 ng/mL group. Conclusion The relationship between procalcitionin, antithrombin Ⅲ and D-dimer in neonates with severe pneumonia has intimate connection. |
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