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| 舍曲林对脑卒中患者抑郁的疗效及对IL-6 IL-1β TNF-α的影响 |
| Efficacy of sertraline in patients with poststroke depression and its effect on IL-6, IL-1β, TNF-α |
| 投稿时间：2015-06-07 修订日期：2015-09-18 |
| DOI：10.3969/j.issn.1000-0399.2015.11.021 |
| 中文关键词: 舍曲林 脑卒中 抑郁症 白细胞介素-6 白细胞介素-1β 肿瘤坏死因子-α |
| 英文关键词: Sertraline Stroke Depression IL-6 IL-1β TNF-α |
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| 中文摘要: |
| 目的 观察舍曲林治疗脑卒中患者抑郁的疗效及对IL-6、IL-1β、TNF-α的影响,探讨其临床适用性。方法 选择2011年1月至2014年10月收治的脑卒中患者150例,简单随机分为试验组和对照组各75例,两组均在常规治疗的基础上,试验组予口服舍曲林,对照组予阿米替林治疗。采用汉密顿抑郁量表(HAMD)、抑郁自评量表(SDS)评估治疗前后抑郁情况,观察两组患者血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平及不良反应发生情况。结果 试验组和对照的总有效率分别为92.0%和70.7%,差异有统计学意义(P < 0.05);两组患者治疗前HAMD、SDS评分比较,差异均无统计学意义(P > 0.05),治疗后两组评分均较治疗前降低(P < 0.05),但试验组优于对照组,差异有统计学意义(P < 0.05);两组患者治疗前IL-6、IL-1β、TNF-α血清水平相当,差异无统计学意义(P > 0.05),治疗后各细胞因子水平均有所下降(P < 0.05),但试验组较治疗组下降更为显著,差异有统计学意义(P < 0.05);两组的不良反应发生情况大致相当,差异无统计学意义(P < 0.05)。结论 舍曲林可以有效改善脑卒中患者的抑郁症状及血清IL-6、IL-1β、TNF-α水平。 |
| 英文摘要: |
| Objective To discuss the efficacy of sertraline in the treatment of depression in stroke patients and its effect on IL-6, IL-1β, TNF-α and its clinical applicability. Methods 150 cases of stroke patients ever treated in our hospital from Jan 2011 to Oct 2014 were selected, and were equally, randomly divided into experiment group and control group. Besides the conventional therapy of stroke, the experiment group was given sertraline, while the control group receiving amitriptyline. The depression status before and after treatment in the two groups were evaluated with HAMD and SDS scale, and the serum IL-6, IL-1β, TNF-α levels and adverse reactions were also observed and recorded. Results The total effective rate in the experiment group and the control group were 92% and 70.7%, respectively, and the difference between them was statistically significant (P < 0.05). There was no significant difference in HAMD and SDS scores before treatment between the two groups (P > 0.05), but after treatment, decrease of HAMD and SDS scores in the experiment group was better than that in the control group with significant difference (P < 0.05). The serum levels of IL-6, IL-1β, TNF-α before treatment in both groups were equivalent in general, with no significant difference (P > 0.05), and the results of these cytokines after treatment decreased totally, but decrease of the experiment group were also better than that of the control group with significant difference (P < 0.05). The adverse reaction between the two groups was roughly the same, with no statistical significance (P > 0.05). Conclusion Sertraline could effectively improve the depressive symptoms in patients with stroke and serum levels of IL-6, IL-1β, TNF-α. |
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