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| 早产儿肺功能发育与脑损伤关系的初步探讨 |
| Preliminary study on the relationship between pulmonary function growth and brain injury in preterm infants |
| 投稿时间：2015-09-01 |
| DOI：10.3969/j.issn.1000-0399.2016.01.007 |
| 中文关键词: 肺功能,检测 早产儿 脑损伤 |
| 英文关键词: Lung function,testing Preterm infant Brain injury |
| 基金项目:安徽省合肥市重大社会发展项目(项目编号:[2012]19-1) |
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| 中文摘要: |
| 目的 探讨早产儿肺功能发育与脑损伤之间的关系。方法 2012年6月至2014年6月入住安徽医科大学第三附属医院新生儿科早产儿,除外肺部感染、需吸氧及机械通气等影响肺功能疾病的早产儿。依据临床表现及头颅MRI结果,分为脑损伤组及非脑损伤组,矫正胎龄40周时行潮气呼吸肺功能检测,比较两组早产儿肺功能的特点及差异。结果 符合入选标准共55例,其中脑损伤组22例(男性12例,女性10例),非脑损伤者33例(男性19例,女性14例)。脑损伤组早产儿呼吸频率[(51.4±6.3)次/min比(42.8±5.8) 次/min,t=5.19]、每分钟通气量[(431.0±84.4)mL/min比(344.3±64.5) mL/min,t=4.31,P<0.05]明显高于非脑损伤组,达峰时间比[(28.1±4.3)%比(35.4±7.2)%,t=-4.27]、达峰容积比[(32.8±2.3)%比(39.9±3.8)%,t=-9.42]、呼气峰流速[(58.7±11.7)mL/s比(67.7±13.7) mL/s,t=-2.54]及75%、50%、25%潮气量时呼气流速[(51.7±8.4)mL/s比(61.6±12.8) mL/s,t=-3.19;(34.4±4.9)mL/s比(47.4±7.4) mL/s,t=-7.23;(31.5±4.0)mL/s比(40.7±7.3) mL/s,t=-6.24,P均<0.05]均明显低于非脑损伤组。结论 脑损伤组早产儿肺功能发育较非脑损伤组早产儿更为不成熟。 |
| 英文摘要: |
| Objective To explore the relationship between lung function growth and brain injury in preterm infants.Method All preterm infants were entered in the study that came from neonatal department,the third affiliated hospital of Anhui Medical University from June 2012 to June 2014,excluding infants suffering from pulmonary infection,oxygen inhalation and mechanical ventilation therapy may affect pulmonary function.The preterm infants were divided as brain injury group and non brain injury group based on the clinical manifestations and brain MRI results,lung function test was performed on them at a postmenstrual age of 40 weeks,and the characteristics and differences in pulmonary function of preterm infants were compared between the two groups.Result Totally 55 preterm neonates who conforms to the selected standards were included in this study; among them,22 neonates (male 12,female 10) were divided as the brain injury group and 33 (male 19,female 14) as the non brain injury group; in the abnormal group,the respiratory rate (RR)[(51.4±6.3) times/min VS (42.8±5.8) times/min,t=5.19] and minute ventilation volume[(431.0±84.4)mL/min VS (344.3±64.5) mL/min,t=4.31,P<0.05]were higher than that in the normal group; Time to peak ratio[(28.1±4.3) %VS (35.4±7.2)%,t=-4.27],the peak volume ratio[(32.8±2.3) %VS (39.9±3.8)%,t=-9.42],peak expiratory flow rate[(58.7±11.7) mL/s VS (67.7±13.7) mL/s,t=-2.54] and tidal expiratory flow 75%remaining tidal volume,tidal expiratory flow 50% remaining tidal volume,tidal expiratory flow 25% remaining tidal volume[(51.7±8.4)mL/s VS (61.6±12.8)mL/s,t=-3.19;(34.4±4.9)mL/s VS (47.4±7.4) mL/s,t= -7.23;(31.5±4.0)mL/s VS (40.7±7.3) mL/s,t=-6.24,P<0.05] were less than that in the normal group; there were significant differences in the above parameters of lung function between the two groups (P<0.05).Conclusion Lung function growth of the premature infants with brain injury are more immature compared with that without brain injury. |
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