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| 妇科恶性肿瘤患者放化疗后感染的危险因素分析 |
| Analysis of risk factors of chemo-radiotherapy-related infections in patients with gynecological cancer |
| 投稿时间：2015-11-26 |
| DOI：10.3969/j.issn.1000-0399.2016.05.020 |
| 中文关键词: 妇科恶性肿瘤 放化疗 感染 危险因素 治疗 |
| 英文关键词: Gynecologic cancer Chemo-radiotherapy Infection Risk factor Treatment |
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| 中文摘要: |
| 目的 探讨不同类型妇科肿瘤患者经放化疗后发生感染的危险因素,研究其最佳的治疗方案。方法 选取2013年1月至2014年8月在我院住院的妇科恶性肿瘤患者100例,收集其痰、咽拭子、胸水、腹水、血液、尿液、粪便标本送检,经过细菌及真菌培养鉴定,分析感染率、感染相关的危险因素及治疗方法。结果 100例标本,共有18例发生感染,感染率为18%,不同类型妇科肿瘤之间比较,差异无统计学意义(P>0.05);从年龄、侵入性操作、白细胞下降、治疗方式、抗菌药物、住院时间等进行单因素分析,发现感染的发生与其均有相关性,差异有统计学意义(P<0.05);进行多因素回归,发现年龄大于60岁、患者状态较差、治疗过程中有侵入性操作、治疗后发生白细胞下降、采用了放疗与化疗结合的治疗方式、治疗过程中应用了抗菌药物、住院时间大于30天,均是造成患者感染的危险因素,差异有统计学意义(P<0.05)。结论 年龄大于60岁、患者状态较差、治疗过程中有侵入性操作、治疗后发生白细胞下降、采用了放疗与化疗结合的治疗方式、治疗过程中应用了抗菌药物、住院时间大于30天,均是妇科恶性肿瘤患者放化疗后发生感染的危险因素。 |
| 英文摘要: |
| Objective To explore the risk factors of infection after chemo-radiotherapy in the patients with different types of gynecological cancer, so as to optimize the antineoplastic protocols. Methods From Jan 2013 to Aug 2014, 100 cases of gynecological cancer patients hospitalized in our hospital were enrolled, and their specimens of sputum, throat swab, hydrothorax, ascites, blood, urine, and stool were collected and identified after bacterial and fungal cultures. The infection rate of patients, infection-related risk factors and antineoplastic protocols were analyzed. Results In the enrolled patients with different types of gynecologic cancer, there were 18 cases of chemo-radiotherapy-related infections were diagnosed through examination of sputum, throat swab, hydrothorax, ascites, blood, urine and stool specimens, with the infection rate of 18%, and the differences among different types of gynecologic cancer were not statistically significant. The univariate analysis of age, invasive procedures, leukopenia, antineoplastic protocols, antimicrobial agents, hospital stays showed that the incidence of infection were correlated with all these six factors, with significant differences. The multivariate regression analysis further showed that age over 60 years old, poor performance status, invasive procedures, leukopenia after treatment, regimen of chemotherapy and radiotherapy, application of antimicrobial agents, and hospital stays more than 30 days were all risk factors of chemo-radiotherapy-related infections in these patients, and there were significant differences. Conclusion Factors of older than 60 years old, poor performance status, invasive procedures, leukopenia after treatment, regimen of chemotherapy and radiotherapy, application of antimicrobial agents, and hospital stays more than 30 days are liable to induce infection after chemo-radiotherapy in patients with gynecologic cancer. |
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