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| 急性脑梗死患者神经功能恢复情况与炎症因子水平的相关性分析 |
| Correlation analysis between neural function recovery and inflammatory factors in patients with acute stroke |
| 投稿时间：2015-11-26 |
| DOI：10.3969/j.issn.1000-0399.2016.05.021 |
| 中文关键词: 脑梗死 神经功能 炎症因子 相关性 |
| 英文关键词: Stroke Neural function Inflammatory factor Correlation |
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| 中文摘要: |
| 目的 分析急性脑梗死神经功能恢复情况与炎症因子的相关性。方法 选取临床确诊的68例急性脑梗死患者为脑梗死组,选择同期体检的60例健康者为对照组,测定两组白介素-1β(IL-1β)、肿瘤坏死因子α(TNF-α)、可溶性细胞间黏附分子1(sICAM-1)、基质金属蛋白酶-9(MMP-9)、同型半胱氨酸(Hcy)、N末端脑钠素原(NT-proBNP)水平,比较脑梗死患者与正常健康人血清炎症因子水平;按照脑梗死体积将患者分为小梗死组(<5 cm3,n=24),中梗死组(5~15 cm3,n=25),大梗死组(>15 cm3,n=19),比较不同梗死体积患者炎症水平;按脑神经缺损程度(NIHSS)评分将患者分为轻度组(0~15分,n=26),中度组(16~30分,n=24),重度组(31~45分,n=18),比较不同脑缺损程度患者炎症因子水平变化。采用Pearson法分析急性脑梗死患者神经功能恢复情况、脑梗死体积与炎症因子水平的相关性。结果 脑梗死组TNF-α、IL-1β、sICAM-1、Hcy、NT-proBNP、MMP-9水平均高于对照组,差异有统计学意义(P<0.05);随脑神经损伤程度、梗死体积的增加,患者TNF-α、IL-1β、sICAM-1、Hcy、NT-proBNP、MMP-9均上升,重度神经损伤、大面积脑梗死组上升最明显(P<0.05);脑神经缺损程度、脑梗死体积与急性脑梗死炎症因子水平呈正相关。结论 急性脑梗死患者炎症因子水平高于正常人,其脑神经损伤程度、脑梗死体积与炎症水平呈正相关。 |
| 英文摘要: |
| Objective To analyze the correlation between neural function recovery and inflammatory factors in the patients with acute stroke. Methods 68 patients with clinical diagnosis of acute stroke were enrolled in the stroke group, and 60 healthy people were enrolled in the control group. The serum levels of interleukin-1 beta(IL-1β), tumor necrosis factor alpha(TNF-α), soluble intercellular adhesion molecule-1(sICAM-1), matrix metalloproteinase-9(MMP-9), homocysteine(Hcy) and N-terminal pro-brain natriuretic peptide(NT-proBNP) in the two groups were examined. Levels of these serum inflammatory factors between the patients with cerebral infarction and the healthy people were compared. According to the infarction volume, the stroke group were further divided into small infarction group(<5 cm3, n=24), medium infarction group(5~15 cm3, n=25) and large infarction group(>15 cm3, n=19). Levels of these inflammatory factors among patients with different infarction volume were compared. According to the scores of National Institutes of Health Stroke Scale(NIHSS), the stroke group were further divided into mild defect group(0~15, n=26), moderate defect group(16~30, n=24) and severe defect group(31~45, n=18). Levels of these inflammatory factors among patients with different neural defects were compared. By the Pearson correlation analysis, the relations among neural function recovery, volume of cerebral infarction and levels of inflammatory factors were analyzed. Results The serum levels of TNF-α, IL-1β, sICAM-1, Hcy, NT-proBNP and MMP-9 in the stroke group were significantly higher than those in the control group(P<0.05). With exacerbation of cranial nerve defect and elevation of infarction volume, the serum TNF-α, IL-1β, sICAM-1, Hcy, NT-proBNP and MMP-9 in the stroke patients generally increased, and the increases in the severe defect group and the large infarction group were most significant(P<0.05). The degree of cranial nerve defect and the volume of cerebral infarction were positively correlated with the levels of these inflammatory factors in patients with acute stroke. Conclusion The levels of these inflammatory factors in the patients with acute stroke are higher than those in the healthy people. The degree of cranial nerve defect and the volume of cerebral infarction are positively correlated with the levels of these inflammatory factors. |
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