| Objective To investigate the pregnancy outcome of twin pregnancy combined with hypoproteinemia. Methods From Jan 2011 to Dec 2015, 140 cases of twin pregnant women without severe gestation complications were collected and therein 90 cases with hypoproteinemia were enrolled in the study group. According to the diagnostic criteria of hypoproteinemia, they were further divided into the severe hypoproteinemia group (serum albumin <20 g/L, n=34) and the mild hypoproteinemia group (20 g/Ln=56). The rest 50 cases with normal albumin level were enrolled in the control group. The general clinical data, results of biochemical examinations and adverse pregnancy outcome between the twin pregnant women of two groups were analyzed and compared. Results The impairments of hepatic and renal function and abnormal lipid metabolism in the patients of study group were more severe than those in the control group in comparison with their biochemical examinations and adverse pregnancy outcome, with significant differences between the two groups (P<0.05). No difference was found in the times of gestation and delivery, BMI, natural conception or in vitro fertilization (IVF), adverse pregnancy history, chorionic conditions between them (P>0.05). In the subgroup comparison of study group, the severe hypoproteinemia group showed more severe impairments of hepatic and renal function and abnormal lipid metabolism than the mild hypoproteinemia group. Meanwhile, the occurrence of such adverse pregnancy outcome as placental abruption, postpartum hemorrhage, fetal growth restriction, and fetal distress in the severe hypoproteinemia group were significantly higher than those in the mild hypoproteinemia group (P<0.05). Conclusion With the onset and progress of hypoproteinemia, the twin pregnant women would suffer from worse impairments of hepatic and renal function and abnormal lipid metabolism, higher risk of such complications as placental abruption, postpartum hemorrhage and puerperal infection, and even perinatal twin adverse outcome. |
