文章摘要
288例发育指标延迟患儿的临床特点分析
Clinical study of clinical features of children with developmental delay: analysis of 288 cases
投稿时间:2016-02-04  
DOI:10.3969/j.issn.1000-0399.2016.10.001
中文关键词: 发育指标延迟  高危因素  临床特点  预后
英文关键词: Developmental delay  Risk factor  Clinical features  Prognosis
基金项目:国家自然科学基金项目(项目编号:81270665)
作者单位E-mail
李静 230032 合肥 安徽医科大学第一附属医院小儿神经康复科  
徐艳红 230032 合肥 安徽医科大学第一附属医院小儿神经康复科  
吴德 230032 合肥 安徽医科大学第一附属医院小儿神经康复科  
唐久来 230032 合肥 安徽医科大学第一附属医院小儿神经康复科 tangjiulai8888@163.com 
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中文摘要:
      目的 对发育指标延迟患儿进行早期诊断、临床特点、高危因素和预后研究分析,为本病的早期诊断及早期干预提供参考。方法 随机选择2014年3月至2015年8月安徽医科大学第一附属医院小儿神经康复科288例发育指标延迟患儿作为研究组,263名正常发育儿童作为对照组,采用问卷形式,对早期诊断、临床特点和危险因素进行分析,采用引导式为主的早期干预措施对治疗组进行干预,并进行6个月的预后随访。结果 发育指标延迟的临床特点以运动发育迟缓最常见(228例,79.1%),认知/感知发育迟缓次之(31例,10.8%),情感交流发育迟缓(22例,7.7%)和语言发育迟缓(7例,2.4%)最低。男孩高发,初诊年龄2~36个月,平均(7.80±4.32)个月,高峰为6~12个月。高危因素主要为新生儿缺氧缺血性脑病(HIE)、早产、新生儿窒息、宫内窘迫及妊娠期高血压等。其中222例患儿随访6个月后发现159例进入正常(71.62%),63例(28.38%)未发育正常,包括发育指标延迟34例(15.31%),全面性发育落后(GDD)14例(6.30%),脑性瘫痪(CP)10例(4.50%)和孤独症谱系障碍(ASD)5例(0.23%)。结论 防治HIE、早产、新生儿窒息、妊娠期高血压等可降低发育指标延迟的发生率。有明显运动、认知/感知、语言发育和情感交流发育指标延迟的患儿应早期诊断,引导式为主的早期干预可改善其预后和降低GDD、CP和ASD等的发生率。
英文摘要:
      Objective To analyze the clinical features of children with developmental delay including early diagnosis,clinical manifestation,risk factors and prognosis,so as to provide a reference for early diagnosis and intervention for these children.Methods A total of 288 cases of children with developmental delay were randomly selected,with 263 cases of typically developing children as the control group.Investigation was made in the form of a questionnaire survey about early diagnosis,clinical manifestation and prognosis of those children,and the risk factors were analyzed.Results In the early manifestations of those children,the most common was motor delay with 228 cases(79.1%),followed by cognition and perceptual retardation with 31 cases(10.8%).22 cases(7.7%) were emotional communication barriers and 7 cases(2.4%) of language delay.Male gender increased the risk of developmental delay.The newly diagnosed age was 7.80±4.32(2-36) months with the peak in 6-12 months.The risk factors were HIE,premature,neonatal asphyxia and gestational hypertension,and so on.Followed up for 6 months,159 cases of 222 cases(71.62%) were normal and 63 cases(28.38%) were abnormal including 34 cases(15.31%) of children with developmental delay,14 cases(6.30%) of global developmental delay,10 cases(4.5%) of cerebral palsy and 5 cases(0.23%) of autism spectrum disorders.Conclusion Prevention and treatment of HIE,premature,neonatal asphyxia and gestational hypertension can reduce the incidence of developmental delay,hence an early diagnosis and timely intervention should be given to improve the prognosis and reduce the incidence of GDD,CP and ASD,especially those with the obvious manifestations of motor,cognitive/perceptual,language and emotional communication developmental delay.
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