| Objective To observe the sedative effect and safetyof dexmedetomidine combined with midazolam during Brachial Plexus Blockade.Methods 120 cases of seleetive surgery patients undergone braehial plexus anesthesia in our hospital from February 2014 to October 2015 were divided randomly and double-blindlyintogroupA,BandC,40cases in each groups.Patients in group A wereanaesthetizedbymidazolam 0.04 mg/kg, group Bweremicro-pumped dexmedetomidine 0.5ug/kg in 10 minutes before brachial plexus blockade and pumped out in 10 minutes, and group C were micro-pumped dexmedetomidine combined with midazolam in 10 minutes before brachial plexus blockade and pumped out in 10 minutes.HR, MAP, SpO2 and OAA/S scores before anesthesia (T0), 10min (T1), 20 min (T2), 30 min (T3), 60 min (T4) during anesthesia, and at the end of operation (T5) of all the patients were recorded and analized.Results Compared with group B and C, the time of maximum sensory block and motion block of group A shortened significantly, the difference was statistically significant (F=5.133, 5.849, P=0.007, 0.004).Compared with T0, the MAP, HR, and OAA/S scores at T1 decreased respectively in group A, and during T1-T4 in group C decreased more apparently, the difference was statistically significant (P<0.05), but at every moment in group B were stable (P>0.05); compared respeetively with group B, the above indexesdecreased obviously only at T1 in group A, but during T1-T4 in group C, besides, the above indexes during T2-T4 in group Cdecreased more obviously than that in group A, the difference was statistically significant (P<0.05); the SpO2 of all the patients were not significantlydifferent (P>0.05); the cases who need atropine to cure the decreased heart rate during the operation in group C were more than that in group A and B, the difference was statistically significant (χ2=7.50,P=0.02).Conclusion Dexmedetomidine which is used during brachial plexus blockade has better sedative effect and safety. |
