| Objective To investigate the related factors of intracranial hemorrhage after urokinase thrombolytic therapy in the patients with cerebral infarction.Methods 280 patients with cerebral infarction, ever treated by thrombolytic therapy in our hospital from Jan 2012 to Sep 2015, were selected and divided into the bleeding group (52 cases) and the non-bleeding group (228 cases) according to intracranial hemorrhage or not examined by head CT or MRI during hospital. Single factor analysis and multivariate logistic regression analysis were performed to analyze the related risk factors of intracranial hemorrhage in these patients with cerebral infarction.Results In the 280 patients with cerebral infarction, the incidence rate of intracranial hemorrhage was 18.57%. Single factor analysis showed that in the comparison between the two groups, differences of seven risk factors, which were pulse pressure, history of atrial fibrillation, NIHSS scores on admission, early ischemic changes, glucose levels on admission, MRS scores on admission and high sensitive CRP levels, were statistically significant (all P<0.05). Multivariate logistic regression analysis showed that glucose levels on admission, history of atrial fibrillation, early ischemic changes and NIHSS scores on admission were independent risk factors for the prognosis of intracranial hemorrhage. Conclusion The higher NIHSS scores and blood glucose levels on admission, history of atrial fibrillation and early ischemic changes would be the risk factors of intracranial hemorrhage in the patients with cerebral infarction. |
