| Objective To evaluate the efficacy and safety of SIMV and HFOV in the treatment of neonatal pneumonia complicating pneumothorax. Methods A retrospectively analysis was done in the clinical data of 24 cases of neonatal pneumonia complicating pneumothorax who accepted mechanical ventilation from Sept 1, 2012 to April 30, 2016, and among them 11 received SIMV and 13 undertook HFO. Data of PaO2, PaCO2 and OI before and 2 hours, 12 hours, 24 hours and 48 hours after mechanical ventilation in two groups were analyzed, so were the time of alveolar recruitment, removal of chest drainage tube, mechanical ventilation and hospitalization. Also, the incidence of intracranial hemorrhage and periventricular leukomalacia was assessed. Results All of the 24 patients were cured. Data of PaO2, PaCO2 and OI after mechanical ventilation were significantly different from those before mechanical ventilation, suggesting the efficacy of the treatment. PaO2, PaCO2 and OI after 2 hours' treatment in HFO group was significantly improved compared with those in SIMV group, so were PaO2 and OI after 12 and 24 hours' treatment. There was no significant difference in alveolar recruitment and thoracic drainage tube removal time between the two groups. Time of mechanical ventilation and hospitalization of SIMV group was longer than that of HFOV group. Cranial MRI examination showed no intracranial hemorrhage, periventricular leukomalacia and other symptoms in both groups. Conclusion Both SIMV and HFOV are effective and safe in the treatment of pneumothorax. HFOV can significantly improve the oxygenation of pneumonia pneumothorax and shorten time of mechanical ventilation and hospitalization as well. |
