| Objective To compare the dosimetric differences of simultaneous integrated boost intensity-modulated radiotherapy and sequential IMRT for lymph-node positive cervical cancer. Methods From Sept 2015 to Augu2016,10 cervical cancer patients with positive lymph nodeswere selected in the First Affiliated Hospital of Anhui Medical University,and all patients underwentinitialdiagnosis. All patients were designed two plans of SIB-IMRT and sIMRT techniques,then the dosimetric parameterswerecomparedin terms of volume target and organ at risk of plans.Results All plans could achieve the clinically acceptable target coverage. The conformity index (CI) of the pGTVnd and PTV in SIB-IMRT was significantly better than that of the sIMRT,and the difference was statistically significant (P<0.05). The V50 andthe maximum dose of the femoral head, small intestine and the rectal of SIB-IMRT were all significantly lower than those of sIMRT(P<0.05).The V30 of SIB-IMRTwas(68.91±8.62, which was higher than the V30 of sIMRT significantly.There was no significant difference between the two methods in items of V40,V50, mean doses and maximum dose of bladder,but the V30 was higher in SIB-IMRT. Conclusion SIB-IMRT can be used for cervical cancer patients with positive lymph nodes,and the CI is better, the better protection of the femoral head,small intestine and the rectalcan be achieved.But the clinical outcome and toxicity needs more research. |
