| Objective To study the relationship between atmospheric fine particles concentration(PM2.5) and children with cough variant asthma. Methods The study was conducted in 48 cases of cough variant asthma and 50 cases of typical asthma, 50 cases of chronic pneumonia and 50 cases of healthy control from April 2015 to April 2016 in Huai'an First People's Hospital, Nanjing Medical University.The mean PM2.5 during onerecent month, serum lymphocyte ratio, CD4+/CD8+T, immunoglobulin IgE and lung ventilation indicatorswere compared. Results The mean PM2.5 in cough variant asthma and typical asthma groups were higher than those in the chronic pneumonia group and healthy control[(85.6±10.3), (76.4±11.4) μg/m3 vs (41.3±12.5), (25.9±10.5) μg/m3(P<0.05)];the lymphocyte ratio and IgE levels were higher, but CD4+/CD8+T was lower in cough variant asthma and typical asthma groups(P<0.05);the FEV1% Pred, FEV1/FVC and MMEF% Pred was (88.7±13.5)%, (80.2±7.8)% and (78.6±15.4)% in the cough variant asthma group, respectively, and (85.4±14.6)%, (76.3±7.6)% and (72.5±16.3)% in the typical asthma group, respectively, all significantly lower than those of the other groups(P<0.05),but were no statistical differences between the cough variant asthma and typical asthma groups (P>0.05). Conclusion PM2.5 is related to children with cough variant asthma, the decrease of the immune regulation and ventilation functions may be related to typical asthma. |
