| Objective To study the correlation between blood pressure and plasma fibrinogen levels in those patients with essential hypertension, and to identify the promoting factors of severe hypertension and association of which with fibrinogen. Methods 258 cases of patients with essential hypertension, admitted to our hospital from Sep 2012 to Dec 2014, were selected and divided into three groups according to their blood pressure levels:the normal pressure group of 68 cases, the grade 1 hypertension group of 63 cases, the grade 2 hypertension group of 79 cases and the grade 3 hypertension group of 48 cases. The plasma fibrinogen levels of patients in the 4 groups were compared by Kruskal-Wallis test and Mann-Whitney U test, and the promoting factors of severe hypertension and association of which with fibrinogen were identified by logistic regression analysis and Spearman correlation analysis, respectively. Results The fibrinogen levels of patients in the grade 3 hypertension group were significantly higher than the results of patients in the other 3 groups (all P<0.01), but differences among the other 3 groups were not statistically significant (all P>0.05). Logistic regression analysis showed that elevated levels of blood glucose (OR=2.746, P=0.004), cholesterol (OR=2.169, P=0.037), creatinine (OR=2.711, P=0.011) and uric acid (OR=2.975, P=0.002) were important promoting factors of grade 3 hypertension development. Spearman correlation analysis indicated that fibrinogen level was unrelated with blood glucose, cholesterol and uric acid, and in weak correlation with blood creatinine. Conclusion Higher fibrinogen level is a promoting factor of blood pressure increase, and elevated levels of blood glucose, cholesterol, creatinine and uric acid all promote the severe hypertension (hypertension grade 3) development. |
