| Objective To investigate the connection between serum chlorine concentration and acute kidney injury (AKI) in those critically ill patients. Methods The clinical data of 83 critically ill patients, hospitalized in our ICU department from Jan 2015 to Dec 2015, were retrospectively analyzed. These patients were divided into the AKI group(21 cases)and the non-AKI group (62 cases), according to definition of acute kidney injury by the Kidney Disease Improving Global Outcomes (KDIGO). The results of serum chlorine concentrations during their ICU stays were collected, and Cl0, Clmax, Clmin, and Clmean were referred to as the initial, maximum, minimum and mean chlorine concentration, respectively. The relationship between serum chlorine concentration and AKI was analyzed. Results Of 83 patients, 21 cases (25.3%) developed AKI, and Cl0 of them were not significantly different from those of other 62 cases (P=0.410). Clmax and Clmean in the AKI group were significantly higher than those in the non-AKI group[(110.10±8.58) vs (105.61±3.64) mmol/L; (103.80±4.96) vs (100.67±5.21) mmol/L], but Clmin in the AKI group was significantly lower than that in the non-AKI group[(93.57±4.84) vs (96.26±4.71) mmol/L] (all P<0.05). Univariate logistic regression analysis showed that Clmax, Clmean and Clmin were all associated with AKI development, and risk of AKI development increased with the growth of Clmax and Clmean, but when Clmin rose, the risk of AKI development had a downward trend. Conclusion Much higher or lower serum chlorine concentration may be associated with AKI development in those critically ill patients, and timely interventions would be needed. |
