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| 5-氟尿嘧啶壳聚糖纳米粒冻干粉的制备 |
| Preparation of 5-fluorouracil chitosan nanoparticles lyophilized powder |
| 投稿时间：2017-01-24 |
| DOI：10.3969/j.issn.1000-0399.2017.09.001 |
| 中文关键词: 5-氟尿嘧啶 冻干粉 冻干保护剂 |
| 英文关键词: 5-fluorouracil Lyophilized powder Lyoprotectant |
| 基金项目:安徽省自然科学基金（项目编号：1508085QH194） |
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| 摘要点击次数: 1832 |
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| 中文摘要: |
| 目的 为研究5-氟尿嘧啶壳聚糖纳米粒冻干粉的制备工艺，提高5-氟尿嘧啶壳聚糖纳米粒的稳定性。方法 首先制备5-氟尿嘧啶壳聚糖纳米粒，并以外观和再分散性为指标，进行单因素考察并利用正交实验优化工艺。结果 5-氟尿嘧啶壳聚糖纳米粒冻干粉的最佳制备工艺为预冻时间24 h、冻干保护剂为甘露醇、用量为80 mg、浓度为10%。冻干前后包封率差异无统计学意义（P>0.05），冻干后的粒径和冻干前相比有一定增大。结论 5-氟尿嘧啶壳聚糖纳米粒冻干粉有望成为新剂型。 |
| 英文摘要: |
| Objective To study the preparation process of 5-fluorouracil chitosan nanoparticles freeze-dried powder and improve the stability of 5-fluorouracil chitosan nanoparticles. Methods Firstly, 5-fluorouracil chitosan nanoparticles were prepared and the appearance and redispersibility of the chitosan nanoparticles were used as indicators. Single factor investigation and orthogonal experiment were used to optimize the process. Results The optimal preparation conditions of freeze-dried powder of 5-fluorouracil chitosan nanoparticles were as follows:pre-freezing time 24 h, the freeze-dried protective agent was mannitol and 80 mg of mannitol at a concentration of 10%. There was no significant change in the encapsulation efficiency before and after lyophilization (P>0.05). The particle size after lyophilization increased compared with that before lyophilization. Conclusion 5-fluorouracil chitosan nanoparticles freeze-dried powder is expected to become a new dosage form. |
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