| Objective To assess the effectiveness of adding dexmedetomidine or midazolam to 0.375% levobupivacaine on ultrasound-guided brachial plexus block.Methods A total of 120 ASA I to Ⅱ patients with forearm and hand surgery under ultrasound-guided brachial plexus block in Wanbei Coal-Electric Group General Hospitalwere recruited in this study and randomly divided into three study groups (n=40 in each), namely, Group L, which received 30 mL 0.375% levobupivacaine, Group LM, which received 30 mL0.375% levobupivacaine with midazolam (50 μg/kg),and Group LD, which received 30 mL 0.375% levobupivacaine with dexmedetomidine(1 μg/kg).The onset time, as well as the duration of sensory and motor block, the duration of analgesia and adverse events were recorded and evaluated.Results The onset time, as well as the duration of sensory and motor block, the duration of analgesia had significant difference when the groups were compared(P<0.05). The onset of sensory and motor block was significantly faster in group LM and group LD compared to that in group L, and the difference was statistically significant(P<0.05). Time of administration of rescue analgesic, duration of sensory and motor block showed significant increase in group LD in comparison with group LM which showed significant increase in comparison with group L, and the difference was statistically significant(P<0.05). The Ramsay sedation score of group LM was higher in group LM than that in group LD without statistical significance(P<0.05), however.No significant difference was observed in the incidence of the adverse events when the groups were compared(P>0.05).Conclusion dexmedetomidine and midazolam in combination with levobupivacaine in ultrasound-guided brachial plexus block are effective in decreasing the onset of sensory and motor block and extending the duration of sensory and motor block and the timeto first analgesic request. In comparison with midazolam, the addition of dexmedetomidine to levobupivacaine is more effective. |
