| Objective To explore the curative effect of intravenous immunoglobulin (IVIG) in treatment of those neonates with acute lung injury or acute respiratory distress syndrome (ALI/ARDS).Methods A total of 60 cases with neonatal ALI/ARDS hospitalized in our hospital from Jan 2014 to Dec 2016 were selected, and then divided into the treatment group and the control group by means of random number table, 30 cases in each group. Besides such symptomatic supportive treatments as mechanical ventilation and pulmonary surfactants, anti-infection and nutrition support for the control group, neonates in the treatment group were given additional IVIG treatment. The serum levels of interleukin-6 (IL-6), IL-10 and tumor necrosis factor-α (TNF-α) before and after treatment, together with ventilation time, hospitalization time and case fatality rate between the two groups were compared.Results Compared with the control group, the serum levels of IL-6 and TNF-α in the treatment group were much lower (Ftime/Between groups/interactive=210.851/50.921/6.258,Ptime/Between groups/interactive<0.01;Ftime/Between groups/interactive=220.613/133.583/11.083, Ptime/Between groups/interactive<0.01),and the IL-10 level after treatment in the treatment group was much higher and differences between the two groups were significant (Ftime/Between groups/interactive=154.547/300.944/43.851, Ptime/Between groups/interactive<0.01). The mechanical ventilation time and hospitalization time in the treatment group were significantly less than those in the control group (P<0.05). The case fatality rate in the treatment group was also significantly lower than that in the control group (P<0.05).Conclusion For those neonates with ALI/ARDS, application of IVIG treatment could reduce their systemic inflammatory responses, shorten the ventilation and hospitalization time, and further decrease the case fatality rate, with advantages of safety and reliability. |
