| Objective To analyze the antimicrobial resistant characteristics and clinical distribution of carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical specimens in a tertiary hospital in Anhui province so as to provide reference data for nosocomial infection control and clinical antibiotic therapy. Methods Clinical information and antimicrobial susceptibility data of CRE isolated from clinical specimens between July 2015 and June 2017 were collected. Distribution characteristics and antimicrobial resistance rate of CRE isolates were analyzed by WHONET5.6, according to CLSI 2016 guideline. Results FromJuly 2015 to June 2017, a total of 82 strains of CRE were isolated from clinical specimens, including Klebsiella pneumoniae (n=42,51.22%), Escherichia coli(n=23,28.05%), Enterobacter cloacae (n=9,10.98%), Serratia marcescens(n=5,6.10%), Citrobacter freundii (n=2,2.44%), and Klebsiella oxytoca(strain 1.22%). The main clinical specimens were sputum specimens (n=29,35.37%), secretion/pus specimens (n=20,24.39%), and urine specimens (n=14,17.07%). They hadwidedistribution in clinical departments, and the main departmens. were ICU (n=14,17.07%), Respiratory Medicine Dept. (n=10,12.20%) and so on. CRE strains showed a high level resistance to routine antibiotics,but only sensitivity to amikacin,andthe resistant rate was 23.17%. Conclusion CRE strain is widely distributed and has a high resistance rate to common antibiotics. Bacterial culture should be carried out actively, and the antibiotics should be rationally selected according to the susceptibility result. Both office of nosocomial Infection control and microbiology laboratory should strengthen the monitoring of CRE. |
