| Objective To explore the relationship between serum 25-hydroxy vitamin D (25-(OH)D) level and peripheral neuropathy in patients with type 2 diabetes mellitus(T2DM). Methods A total of 128 T2DM patients hospitalized from Jan 2016 to Apr 2017 in the Department of Endocrinology in Anhui Provincial Hospital were enrolled in this study, including 78 subjects with diabetic peripheral neuropathy (DPN group) and 50 without peripheral neuropathy (NDPN group). Biochemical indicators such as age, height, weight, gender, duration, systolic blood pressure(SBP), diastolic blood pressure(DBP) were collected, body mass index (BMI) was calculated, and serum 25(OH)D, HbA1c, insulin c-peptide, serum calcium(Ca), serum phosphorus(P), alkaline phosphatase(ALP), triglycerides (TG), total cholesterol, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured. Pearson's analysis was used to assess the relationship between 25(OH)D and other markers. Logistic regression analysis was applied to show independent predictors for the presence of DPN. Results Compared with NDPN group, the level of 25(OH)D decreased significantly in DPN group (P<0.05), and 25(OH)D was negatively associated with HbA1c(r=-0.467, P<0.05), duration(r=-0.432, P<0.05) and LDL-c(r=-0.439, P<0.05). Logistic regression analysis showed that 25(OH)D was an independent predictor of DPN.Conclusion Vitamin D insufficiency is associated with diabetic peripheral neuropathy. |
