| Objective To investigate the effects of intraoperative body temperature protection on early postoperative cognitive dysfunction (POCD) and serum levels of brain injury biomarkers in those elderly patients undergoing transurethral vaplrization of prostate (TUVP). Methods From Feb 2017 to Sep 2017, sixty elderly patients underwent TUVP treatments in our hospital were collected, and then were equally divided into the room temperature group (control group) and the body temperature protection group (trial group) by means of random number table. Patients in the control group had their non-operative regions covered with cotton quilts, and all intravenous infusion injections and resection irrigation fluids used were at room temperature. But patients in the trial group had their non-operative regions covered with hot wind heating blankets, and temperature of all intravenous injections and irrigation fluids were kept at 38℃. All patients were scored with the mini-mental state examination (MMSE) scale for assessment of their mental function at 1 day before operation (D1), 1 day after operation (D2) and 3 days after operation (D3). Meanwhile, their blood levels of brain injury biomarkers (MBP, NSE and S-100 β proteins) at these time points were also detected. The incidences of POCD, together with changes of MBP, NSE and S-100 β proteins, at each time point between the two groups were further compared. Results At the time points of D2 and D3, incidences of POCD in the control group were 26.67% and 6.67%, respectively, which were significantly higher than those in the trial group (6.67%, 0; P<0.05). Although there was no significant difference between the two groups in the MBP, NSE and S-100 β proteins levels at the D1 time point, but at the D2 and D3 time points, levels of MBP, NSE and S-100 β proteins in the trial group were much lower than those in the control group, with statistically significant differences (P<0.05). Conclusion Intraoperative body temperature protection could be used as an effective protective measure for POCD prevention, because it can effectively reduce the incidence of POCD and the serum levels of brain injury specific biomarkers (MBP, NSE and S-100 β proteins) in elderly patients. |
