| Objective To explore the value of serum levels of cystatin C (Cys-C) and homocysteine (HCY) in the prediction of intracranial vascular lesions of ischemic cerebrovascular diseases. Methods 112 patients with acute ischemic cerebrovascular diseases hospitalized in our hospital between Jan 2017 and May 2017 were chosen as the study objectives (disease course within 2 weeks). The age, gender, whether or not with risk factors for vascular diseases (such as hypertension, coronary heart disease, diabetes, hyperlipemia, etc.), and history of smoking and drinking of all patients were recorded. Biochemical instruments were used to detect their serum levels of TC, HDL, LDL, Cys-C and HCY, and cranial MRA examination was also conducted on them. According to degree of vascular stenosis and number of diseased vessels, all patients were grouped respectively, and differences of each risk factor for vascular lesions, levels of Cys-C and HCY among different groups were compared. Meanwhile, Spearman-related analysis was applied to identify the relevance of Cys-C and HCY levels with different degrees of vascular stenosis and numbers of diseased vessels. Results Age, drinking, hypertension and diabetes were all associated with the degree of intracranial vascular stenosis (P<0.05), and hypertension was further associated with the number of diseased intracranial vessels (P=0.012). The Cys-C and HCY levels were both correlated to the degree of intracranial vascular stenosis and the number of diseased intracranial vessels (all P<0.01). As shown by Spearman correlation analysis, the Cys-C level was positively correlated to the vascular stenosis degree and the diseased vessel number (r=0.489; r=0.571; P<0.01), and the HCY levels was also positively correlated to them (r=0.493; r=0.459; P<0.01). Conclusion The serum levels of Cys-C and HCY might be positively correlated to the degree of atherosclerotic stenosis in intracranial vessels, and combined examination of Cys-C and HCY could predict the degree of intracranial vascular lesions in those patients with ischemic cerebrovascular diseases. |
