| Objective To investigate the relationship betweenserum ferritin level and diabetic peripheral neuropathy (DPN) in elderly patients with diabetesand the possible mechanism.Methods A total of 548 cases of elderly patients with T2DM from January 2011 to August 2017 in Wuhu Second People's Hospital were divided into non-DPN group (NDPN group,n=304) and DPN group(n=244) according to the double lower limb EMG. On the other hand, 220 cases of healthy persons treated in the hospital during the same period were selected as control group (NCgroup). Body mass index (BMI),blood pressure (BP), orgotein superoxide dismutase (SOD), total cholesterol (TC), triglyceride(TG), endothelin (ET), serum ferritin (SF), glycated hemoglobin (HbA1c) and nitric oxide (NO) were measured and analysed, andthe potential risk factors for DPN were further calculated by Logistic regression analysis.Results Except for the HDL-C index, there were significant differences among the DNP, NDNP and NC groups (P<0.05). HbA1c, ET, TC, TG, LDL-C and SF were higher inDPN group than those in NDPN and NCgroup, while SOD and NO were lower than those in NDPN and NC group. There were statistically significant differences (P<0.05;P<0.01). The results of correlation analysis showed that SF was positively correlated with HbA1c, TC, TG and ET (r=0.613,0.461,0.542,0.583;P<0.05). On the other hand, SF was negatively correlated with SOD and NO (r=-0.432,-0.574; P<0.05). Logistic regression analysis of DPN related factors showed that SF and ET were the independent risk factors of DPN, and that SOD and NO were the protective factors.Conclusion Serum ferritin is an independent risk factor for DPN in elderly diabetic patients, and it may be involved in the pathogenesis of DPN through oxidative stress. |
