| Objective To investigate the significance of C-reactive protein(CRP) in the prediction of gangrenous and perforated appendicitis(GPA).Methods This analysis was based on the clinical data of 111 appendectomy cases in the Third People's Hospital of Bengbufrom October, 2016 to October, 2017. According to the surgical operation and pathological results, the sample consisted of three groups, including 43 patients with acute simple appendicitis, 48 patients with acute phlegmonous appendicitis, and 20 patients with gangrenous and perforated appendicitis. Based on the following three index, the white blood cell(WBC) count, the percentage of neutrophils (N%), CRP level, this study was accomplished with Logistic regression analysis and resulted in Receiver Operating Curve(ROC).Results The difference of CRP level and WBC count between the three groups was statistically significant (P< 0.05). The level of CRP in group GPA was higher than that in group ASA and APA. The WBC count of group ASA was lower than that in APA and GPA group, and the difference was statistically significant (P< 0.05). The logistic regression analysis results showed that CRP was the predictive risk factor for GPA(P=0.001). The ROC curves showed that the index CRP was superior to WBC count and N% in determining GPA. The areas under the curve were 0.617, 0.610 and 0.797 respectively of WBC count,N% and CRP(P=0.000)), of which the Youden index was 0.464, and the best diagnostic cutoff value was 41.94mg/l (sensitivity 75.00%, specificity 71.43%).Conclusion The increase of CRP level in patients with GPA is more obvious, which can be used as an auxiliary indicator for predicting the pathological type of appendicitis. |
