| Objective To investigate the relationship between blood glucose fluctuation and cerebral infarction in type 2 diabetic mellitus(T2DM).Methods A total of 163 patients with type 2 diabetes, who were hospitalized in the Department of Endocrinology in the Second People's Hospital of Hefei from January to December in 2016, were divided into two groups(T2DM group and cerebral infarction group). All patients were monitored with 72 h continuous glucose monitoring system (CGMS), then the correlation between glucose fluctuation related indicators (such as mean blood glucose, large amplitude of glycemic excursions,blood glucose fluctuation coefficient, average fasting blood glucose) and cerebral infarction was analyzed. Results Large amplitude of glycemic excursions (LAGE) and blood glucose fluctuation coefficient(BGFC) of DCI group were significantly higher than those of the DM group, (10.71±3.10) mmol/L vs (9.61±3.19) mmol/L and 2.46±0.81 vs 2.13±0.65 (P<0.05). But there was no significant difference in the average fasting blood glucose (AFBG), mean blood glucose (MBG) and HbA1c between the two groups. Compared with DM group, the incidence of diabetic retinopathy and peripheral vascular diseases significantly increased in DCI group. Conclusion Compared to the continuous hyperglycemia, blood glucose fluctuation is more likely to cause cerebral infarction in patients with type 2 diabetes. |
