| Aim To investigate the relationship between Hcy and serum apolipoprotein B/apolipoprotein A1 in elderly patients with H-type hypertension. Methods A total of 204 elderly patients with H-type hypertension treated in the Third People's Hospital of Hefei hospital from 2016 to 2018 were selected and divided into two groups, namely, H-type hypertension group (≧10 μmol/L) as group A (n=144) and the non-H-type hypertension group (< 10μmol/L) as group B (n=60), according to the values measured in plasma homocysteine. Serum apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) levels were monitored, the ratio was calculated, and the two groups' blood pressure, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), uric acid (UA), fasting plasma glucose (FPG), creatinine (CREA), urea nitrogen (GREA) were collected at the same time. The differences between the two groups in clinical data and ApoB/ApoA1 ratio were compared. Pearson linear analysis was used to analyze the correlation between high Hcy and various factors, and binary Logistic regression was used to analyze the influencing factors of h-type hypertension. Results The male ratio, age, hypertension course, Hcy, ApoB, ApoB/ApoA1 ratio, UA and CREA of group A were all higher than those of group B, with statistically significant difference (P<0.01). There was a positive correlation between Hcy and ApoB/ApoA1 ratio, UA and CREA (r=0.234, 0.250, 0.223, P<0.05). Logistic regression analysis showed that ApoB/ApoA1 was a risk factor for type H hypertension in the elderly (OR=43.822, P<0.001). Conclusion There is a correlation between Hcy and ApoB/ApoA1. |
