| Objective To investigate the effect of recombinant human brain natriuretic peptide on cardiac function and tissue perfusion after PCI in elderly patients with acute myocardial infarction. Methods A total of 96 elderly patients with acute myocardial infarction hospitalized for PCI in our hospital from Sept 2015 to Feb 2017 were selected. According to the random number table method, they were divided into control group and observation group, with 48 cases in each group. The patients in control group were treated with routine therapy of acute myocardial infarction, and those in observation group with recombinant human brain natriuretic peptide on the basis of routine therapy. Cardiac function[left ventricular end-diastolic diameter (LVEDd), interventricular septal thickness (IVSTT), left ventricular posterior wall thickness (LVPWTT), early to late diastolic maximal blood flow ratio (E/A), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF)] and major adverse cardiac events were compared. Results Heart related indexes:after treatment, the cardiac index of the patients in observation group was 4.12±0.34μ g/mL, which was higher than that in control group (3.68±0.43). The lactate level of the patients in observation group was 2.51±0.34) mmol/L and the N-terminal brain natriuretic peptide (NT-proBNP) level was 14.72±5.21) ng/mL, which was significantly lower than that in control group (3.42±0.522 mmol/L and 18.14±4.32 ng/mL, P<0.05). Myocardial perfusion:After treatment, the ratio of TIMI grade 3 in observation group was higher than that of control group. The TIMI frame number (CTFC) (27.62±4.74) was lower in observation group than in control group (37.34±5.11), and the difference was statistically significant (P< 0.05). Cardiac function index:after treatment, there was no significant difference in LVEDd between the two groups. The IVST, LVPWT, LVMI in observation group was lower than that in control group. E/A and LVEF in observation group was higher than that in control group, and the difference was statistically significant (P<0.05). Adverse cardiac events:six months after operation, the incidence of severe heart failure in observation group was 2.08%, lower than that in control group (20.83%, P<0.05). Conclusion The application of recombinant human brain natriuretic peptide on the basis of routine therapy in elderly patients with acute myocardial infarction after PCI is beneficial to the improvement of cardiac function and tissue perfusion. |
