| Objective To observe the clinical efficacy and safety of laparoscopy and choledochoscopy combined with Shugan Lidan granules composed of twelve traditional Chinese medicine in the treatment of extrahepatic bile duct stones. Methods Forty-eight cases of extrahepatic bile duct stones who were admitted to this hospital from Jan 2013 to Dec 2016 were divided into the study group and the control group according to the randomized controlled trial, with 24 cases in each group. The control group was treated with double mirror combined therapy, namely laparoscopic common bile duct exploration and intraoperative choledochoscopy for exploration and removal. On the basis of the control group's treatment, the study group was given Shugan Lidan granules composed of twelve traditional Chinese medicine. After treatment, the clinical efficacy and related indexes of the two groups were observed. Results In the comparison of the clinical effects of two groups, the total effective rate of control group was 91.67%, that of study group was 95.83%, and there was no statistically significant difference(P>0.05). The recovery time of gastrointestinal function in study group was(24.72±4.13)h, eating time(33.14±4.91)h and hospitalization time(8.16±2.35)d, which were significantly shorter than those in control group(P< 0.05). In two groups of patients before and after treatment, the differences in blood routine indicators, liver function indicators, serum bile biochemical indicators between the two groups were statistically significant(P<0.05). The bile flow rate of study group was(669.10±113.65) mL and(860.53±126.26) mL on 5th d and 7th d, respectively, which was significantly higher than that in control group. The difference between two groups was statistically significant(P<0.05). After 12 months of follow-up, the recurrence rate of study group(4.17%) was significantly lower than that of control group(12.50%)(P<0.05). Conclusion Laparoscopy and choledochoscopy combined with Shugan Lidan granules composed of twelve traditional Chinese medicine can improve the success rate of operation, have better control of postoperative biliary inflammation, promote rapid recovery of liver function, reduce postoperative complications, and prevent recurrence of stones. |
