| Objective To observe the effect of comfort shallow sedative strategy in postoperative esophagus cancer patients with mechanical ventilation. Methods A prospective randomized controlled study was used, altogether 200 postoperative esophagus cancer patients with mechanical ventilation in ICU of Anhui Provincial Cancer Hospital from January 2017 to April 2018were recruited in the study. According to the order of entering ICU time, patients were divided into two groups by random digits table method, with 100 patients in each group. Patients in observation group established comfort shallow sedative strategy operational procedures and those in control group received conventional drug sedation and analgesia treatment (sufentanil,disoprofol,dexmedotomidine).Then the dosage of sedation drugs, the Ramsay score and the RASS score, the time of mechanical ventilation, the ICU time, the incidence of unplanned extubation, incidence of delirium and incidence of orientation obstacle in a month out of ICU between two groups were compared and analysed. Results The dosage of sedation drugs in observation group was:disoprofol (5 652.00±526.45) mg, dexmedotomidine (1 640.50±387.22) μg, the mechanical ventilation time was (4.56±0.77) d and the ICU time was(5.98±0.89) d, which were all lower than those in control group, and the difference was statistically significant (P<0.05). The Ramsay score (3.32±0.55)s and the RASS score (-1.32±0.85)s in observation group were closer to the sedation goal, and the difference was statistically significant (P<0.05). The incidence of delirium in observation group was lower than that in control, and the differencewas statistically significant (P<0.05). The incidence of unplanned extubation and the disorientation in a month out of ICU between the two groups had no statistical difference (P>0.05). Conclusion The application ofcomfort shallow sedative strategy in postoperative esophagus cancer patients with mechanical ventilation could effectively reduce the dosage of sedatives, shorten the mechanical ventilation and the ICU time,and reduce the incidence of delirium, which is worthy of further clinical popularization and application. |
