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| 托烷司琼复合地塞米松对扁桃体切除术患儿术后恶心呕吐的预防效果 |
| Efficacy of tropisetron combined with dexamethasone for preventing postoperative nausea and vomiting after tonsillectomy in children |
| 投稿时间：2018-03-21 |
| DOI：10.3969/j.issn.1000-0399.2018.12.015 |
| 中文关键词: 托烷司琼 氟哌利多 地塞米松 术后恶心呕吐 扁桃体切除术 |
| 英文关键词: Tropisetron Droperidol Dexamethasone Postoperative nausea and vomiting Tonsillectomy |
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| 中文摘要: |
| 目的 比较托烷司琼或氟哌利多复合地塞米松对扁桃体切除术患儿术后恶心呕吐（PONV）的预防效果。方法 选择东南大学附属中大医院江北院区2017年1月至2018年1月择期行双侧扁桃体（或合并腺样体）切除术患儿240例，随机分为地塞米松组（D组）、托烷司琼复合地塞米松组（TD组）与氟哌利多复合地塞米松组（FD组），每组80例。在麻醉诱导时，D组静脉注射地塞米松250 μg/kg、TD组静脉注射托烷司琼100 μg/kg+地塞米松250 μg/kg，FD组静脉注射氟哌利多10 μg/kg+地塞米松250 μg/kg。分析3组患儿术后24 h内PONV、术后呕吐（POV）及24 h后PONV、POV的差异。结果 TD组患儿24 h内PONV、24 h内POV、补救呕吐的发生率均低于D、FD组，差异有统计学意义（P<0.017）；D、FD组患儿24 h内PONV、24 h内POV、补救呕吐的发生率差异无统计学意义（P>0.017）。结论 托烷司琼复合地塞米松可以降低扁桃体切除术患儿PONV的发生。 |
| 英文摘要: |
| Objective To compare the efficacy of tropisetron or droperidol combined with dexamethasone for preventing postoperative nausea and vomiting (PONV)after tonsillectomy in children. Methods A total of 240 children admitted to Jiangbei District of Zhongda Hospital, Southeast University from Jan. 2017 toJan. 2018 and scheduled for elective tonsillectomy were enrolled in this study. These patients were divided into three groups (n=80 each) randomly. During anesthesia induction, patients were respectivelyinjected 250 μg/kg dexamethasonein groupD, 100 μg/kg tropisetron+250 μg/kg dexamethasone in group TD and 10 μg/kg droperidol +250 μg/kg dexamethasone in group FD intravenously. The rates of PONV and postoperative vomiting (POV) within 24 postoperative hours, PONV and POV after 24 postoperative hours were detected and the difference among groups wasanalyzed. Results The proportion of PONV, POV and the incidence of remedial vomiting within 24 hours in group TD wereall lower than thosein group D and group FD, and the difference was statistically significant (P<0.017). There was no statistically significant difference in the proportion of PONV, POV and the incidence of remediation vomiting within 24h between group D andgroup FD (P>0.017). Conclusion The combination of tropisetron and dexamethasone is effective to decrease PONV after pediatric tonsillectomy. |
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