| Objective To explore the correlation of Apelin-13 and bone density in patients with type 2 diabetes.Methods From Aug 2016 to Aug 2017, 150 patients with type 2 diabetes were randomly selected from the Second Affiliated Hospital of Xi'an Medical University. According to WHO osteoporosis diagnostic criteria, normal bone mass group, bone mass reduction group and osteoporosis group, 50 cases in each. The glycosylated hemoglobin analyzer detect HbAlc levels at the fingertips. ELISA was used to detect Apelin-13 levels in serum. Radioimmunoassay was used to the levels of 25 (OH) D3, PINP, and ICTP in serum. The results of general data, HbAlc, Apelin-13, PINP, ICTP, 25 (OH) D3 and bone density were compared. The correlation between Apelin-13 and PINP, ICTP, 25 (OH) D3 level and the bone density of each test site were analyzed.Results The osteoporosis group Apelin -13, 25 (OH) D3, BMD level wthe lowest (820.44±73.62) pg/mL,(7.54±0.95) nmol/L, the bone mass reduction, and the normal bone mass group was the highest. The osteoporosis group had the highest level of PINP and ICTP(1 332.74±126.45) pg/mL,(496.32±55.42)μg/L, the lower bone mass group, and the normal bone mass group was the lowest(P<0.05). Correlation analysis showed that serum Apelin-13 level significantly negatively correlated with serum PINP and ICTP levels (r=-0.7234,-0.8514,P<0.05). There was a positive correlation with serum 25 (OH) D3 level (r=0.9533,P<0.05). There was a significant positive correlation between the bone density(P<0.05). Conclusion Patients with type 2 diabetes with osteoporosis low serum Apelin-13, 25 (OH) D3 and high levels of PINP and ICTP. Apelin-13 may be involved in bone resorption and bone formation in diabetic patients. |
