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| 沙库巴曲缬沙坦与缬沙坦治疗慢性心力衰竭的早期临床疗效比较 |
| Comparison of early clinical efficacy of sacubitril/valsartan(LCZ696) and valsartan in treatment of chronic heart failure |
| 投稿时间：2019-02-13 |
| DOI：10.3969/j.issn.1000-0399.2019.06.005 |
| 中文关键词: 沙库巴曲缬沙坦 慢性心力衰竭 缬沙坦 疗效 |
| 英文关键词: Sacubitril valsartan Chronic heart failure Valsartan Efficacy |
| 基金项目:安徽省卫生和计划生育委员会科研计划项目（项目编号：2016QK017） |
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| 中文摘要: |
| 目的 比较沙库巴曲缬沙坦与缬沙坦治疗慢性心力衰竭的早期临床疗效。方法 选取2018年3~9月在安徽医科大学附属第二医院心内科确诊慢性心力衰竭患者70例，按照随机数字表法分为观察组和对照组，每组各35例，两组患者在慢性心力衰竭常规基础治疗上，观察组予沙库巴曲缬沙坦口服，对照组予缬沙坦口服，出院30 d后门诊随访时，比较两组患者左室射血分数、6 min步行试验、二次住院率等指标的差异。结果 出院治疗30 d后，两组患者左室射血分数较入院前均有改善，观察组较对照组改善更为明显，差异有统计学意义（P<0.05）；两组患者6 min步行试验较入院时均有改善，观察组与对照组比较，6 min步行试验结果改善明显，差异有统计学意义（P<0.05）；观察组30 d内再住院率低于对照组，但差异无统计学意义（P>0.05）。结论 沙库巴曲缬沙坦较缬沙坦能显著改善慢性心力衰竭患者心功能，以及改善出院30 d后的活动耐量。 |
| 英文摘要: |
| Objective To investigate the early clinical efficacy of sacubitril/valsartan on patients with chronic heart failure compared with that of valsartan alone. Methods From March to September 2018, a total of 70 patients with chronic heart failure were selected from the Department of Cardiology, the Second Hospital of Anhui Medical University and randomized to observation group and control group, with 35 cases in each group. Based on routine anti-heart failure treatment, patients in observation group received sacubitril/valsartan, while those in control used valsartan. Both groups undertook continuous treatment for 30 days. The changes of left ventricular ejection fraction(LVEF), 6-minute walk test distance and hospital readmission of heart failure were recorded and compared after treatment. Results After 30 days of treatment, LVEF and the 6-minute walk test distance in two groups were improved compared with those before treatment. LVEF and the 6-minute walk test distance in observation group was superior to those in control group (P<0.05). The hospital readmission rate of observation group was lower than that in control group, but there was no significant difference between the two groups (P>0.05). Conclusion Compared with valsartan, sacubitril/valsartan can markedly improve the cardiac function and activity tolerance in patients after 30 days of discharge. |
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