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| 血小板聚集率及血小板平均体积预测急性冠脉综合征术后主要心血管事件的价值 |
| Value of platelet aggregation rate and mean platelet volume in predicting cardiovascular events after ACS |
| 投稿时间：2019-04-27 |
| DOI：10.3969/j.issn.1000-0399.2019.11.009 |
| 中文关键词: 急性冠脉综合征 血小板平均体积 血小板聚集率 心血管事件 |
| 英文关键词: Acute coronary syndrome Mean platelet volume Platelet aggregation rate Major cardiovascular events |
| 基金项目:南京市医学科技发展资金资助（项目编号：QRX17212） |
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| 中文摘要: |
| 目的 评价血小板聚集率（PAR）、血小板平均体积（MPV）对急性冠脉综合征（ACS）患者支架术后在院期间发生主要心血管事件（MACE）的预测价值。方法 选取2016年1月至2018年12月在南京市高淳人民医院行经皮冠状动脉介入治疗（PCI）的206例ACS患者，根据PCI术后是否发生MACE，分为MACE组（n=31）与非MACE组（n=175），分析MPV、PAR与MACE的关系。采用受试者工作特征曲线（ROC）法评价二者作为MACE预测指标的价值，应用logistic回归分析ACS发生MACE的影响因素。结果 MACE组患者MPV为（13.14±1.73）fl，PAR为（55.49±7.21）%，高于非MACE组，差异有统计学意义（P<0.05）。MPV和PAR可作为预测ACS支架术后在院期间MACE的指标，其曲线下面积（AUC）分别为0.883（0.814～0.953）和0.842（0.761～0.932），其最佳诊断界值为11.53 fl和50.67%，并且MPV、PAR是发生MACE的危险因素。结论 MPV与PAR可作为预测ACS患者支架术后在院期间发生MACE的指标。 |
| 英文摘要: |
| Objective To evaluate the predictive value of platelet aggregation rate(PAR) and average platelet volume(MPV) for cardiovascular events(MACE) after stenting in patients with acute coronary syndrome(ACS). Methods A total of 206 ACS patients who underwent PCI in gaucun people's hospital of Nanjing from January 2016 to December 2018 were selected and divided into MACE group(n=31) and non-mace group(n=175) according to whether MACE events occurred in the hospital after PCI.The relationship between MPV and PAR and MACE was analyzed.The value of the two as MACE predictors was evaluated by ROC. Multivariate logistic regression was applied to analyze the influencing factors of the occurrence of MACE in ACS. Results The MPV of MACE group was (13.14±1.73) fl and PAR(55.49±7.21)%,which were higher than those of non-mace group(P<0.05).The AUC was 0.883(0.814~0.953) and 0.842(0.761~0.932),respectively.The optimal diagnostic threshold was 11.53 fl and 50.67%,and the increase of MPV and PAR were risk factors for the occurrence of MACE. Conclusion MPV and PAR can be used as predictors of cardiovascular events in patients with ACS after stenting in hospital. |
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