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| 某市孕妇妊娠早中期血清维生素A E水平调查 |
| Status of vitamin A and vitamin E nutrition in pregnant women in early and middle stages in Maanshan City |
| 投稿时间：2019-04-12 |
| DOI：10.3969/j.issn.1000-0399.2019.12.009 |
| 中文关键词: 维生素A 维生素E 妊娠期 优生优育 |
| 英文关键词: Vitamin A Vitamin E Pregnancy Prenatal and postnatal care |
| 基金项目:国家卫计委医药卫生科技发展研究中心立项项目（项目编号：W2016CWAH02）；马鞍山市科技计划项目（项目编号：YL-2017-01） |
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| 中文摘要: |
| 目的 调查马鞍山市孕妇妊娠早、中期血清维生素A、E水平，为促进孕期营养保健和实现优生优育提供保障。方法 选取2017年3月至2018年6月在马鞍山市妇幼保健院早孕建册的孕妇6 392例，分别于妊娠早期（孕≤ 14周）、中期（孕24~28周）产前检查时进行血样采集，同时将孕妇按年龄分为4组，采用高效液相色谱法定量测定其血清维生素A、E的浓度，分析异常率及其原因。结果 共收集孕妇血清样10 658份，其中妊娠早期6 392份，妊娠中期4 266份。妊娠早、中期维生素A水平分别为（0.40±0.09） mg/L和（0.42±0.09） mg/L；维生素A异常以缺乏为主，缺乏率分别为9.53%和7.17%；妊娠早期维生素A缺乏率高于妊娠中期，差异有统计学意义（P < 0.001）。妊娠早、中期维生素E水平分别为（10.78±2.94） mg/L和（14.60±3.34） mg/L；维生素E异常以过量为主，过量率分别为0.75%、5.44%；妊娠中期维生素E过量率高于妊娠早期，差异有统计学意义（P < 0.001）。年龄分组结果显示，妊娠早期不同年龄组维生素A缺乏率差异有统计学意义（P < 0.05），妊娠中期不同年龄组维生素E过量率差异有统计学意义（P < 0.05）。结论 马鞍山市孕妇妊娠早期维生素A缺乏和妊娠中期维生素E过量情况较明显，应重视孕期维生素A、E的监测，加强孕期营养指导和合理补充，提高母婴健康水平。 |
| 英文摘要: |
| Objective To study and analyse the serum levels of vitamin A, vitamin E to promote nutrition in pregnancy and to provide guarantee for the realization of pre-natal and pre-natal care.Methods The pregnant women who registered early pregnancy in Ma'anshan Maternal and Child Health Hospital from March 2017 to June 2018were selected. Blood samples were collected during antenatal examinationsinthe early stage of pregnancy(≦14 weeks ofgestation)andin the second trimester(24-28 weeksof gestation). Meanwhile, pregnant women were divided into < 25-year-old group, 25-year-old group, 30-year-old group and 35 to 45-year-old group according to their age.The levels of vitamin A and vitamin E were determined by high-performance liquid chromatography. Abnormal conditions and difference of vitamin A and E in early and middle pregnancy were analysed.Results A total of 10 658 serum samples of pregnant women were collected, of which 6 392 were in the first trimester and 4 266 the second trimester. The levels of vitamin A in early and middle pregnancy were (0.40±0.09) mg/L and (0.42±0.09) mg/L, respectively. The deficiency of vitamin A in early pregnancy was significantly higher than that of the second trimester (9.53% vs 7.17%, P < 0.001). The levels of vitamin E in early and middle pregnancy were (10.78±2.94) mg/L and (14.60±3.34) mg/L, respectively; the overdose rates of vitamin E in second trimester were significantly higher than those of early pregnancy (0.75% vs 5.44%, P < 0.001). Analysis by age group showed that the younger the age, the higher the rate of vitamin A deficiency in early pregnancy (P < 0.001); the older the age, the higher the rate of vitamin E excess in the second trimester (P < 0.001).Conclusions The levels of vitamin A and E are different in early and middle pregnancy. The deficiency of vitamin A in early pregnancy and the excess of vitamin E in second trimester are obvious. Attention should be paid to the monitoring of vitamin A and E during pregnancy. The nutrition guidance and reasonable supplementation should be highly promoted during pregnancy to improve the health of mothers and infants. |
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