Objective To observe the effects of propofol and seven halothane on the oxidative stress response and prognosis of patients with intracranial aneurysms in order to provide reference for the selection of narcotic drugs.Methods A total of 146 patients with intracranial aneurysm underwent general anesthesia were enrolled as the study subjects. The cases were all from Nanyang Central Hospital. The study period was from January 2017 to May 2018. They were divided into propofol group (73 cases) and sevoflurane group (73 cases) by random number table method. All of them were induced by dexmedetomidine, fentanyl and midazolam. The difference intime of blinking, time of extubation and time of complete recovery after anesthesia were compared between the two groups. Serum levels of superoxide dismutase (SOD), catalase (CAT) of the two groups were assessedinthe pre-anesthesia (T1) and 12h (T 2), 24h (T 3), 48h (T 4),and 72h (T 5).The prognosis of the two groupswas evaluated using Glasgow Outcome Score (GOS) three months after operation.Results The propofol group had a blinking time of (9.9±2.3) min, a extubation time of (13.4±2.8) min, a complete recovery time of (21.3±3.7) min, and sevoflurane group had(10.1±2.4) min, (12.9±2.7) min, and (20.9±3.9) min, respectively; there was no significant difference between the groups (P>0.05).There was no significant difference in serum SOD, CAT activities between the two groups (P>0.05). The activities of SOD, CAT at T 2~T 5 were significantly lower than those atT 1 (P<0.05), in which the propofol group was significantly lower than the sevoflurane group (P<0.05). There was no significant difference in GOS score between the two groups three months afteroperation(P>0.05).Conclusion Propofol and sevoflurane are used to maintain general anesthesia in patients with intracranial aneurysm interventional embolization. The anesthesia effect and prognosis are similar, but sevoflurane can significantly reduce oxidative stress response in patients with propofol,indicating its potential significance in reducing brain tissue damage. |