| Objective To investigate the effects of geniposide on learning and memory impairments in sleep-deprived model rats, and to provides reference basis for improving the ability of learning and memory in patients with sleep deprivation. Methods Fifty adult male Sprague-Dawley rats were divided normal control (n=10, rats were normally fed without sleep deprivation and treatmant), SD group (n=10, sleep deprivation model group), low-dose geniposide treatment groupn (n=10; 10 mg/kg), middle-dose geniposide treatment group (n=10; 20 mg/kg), and high-dose geniposide treatment group (n=10; 40 mg/kg) by random digital table. Light touch and cage exchange methods were used to establish rat models of sleep deprivation. After one week of intervention, the rats in each group were observed and compared regarding the escape latency and spatial probe ability (the number of cross-platform and the time in first arriving at the assumed platform). Results After one week of intervention, the escape latency was significantly longer in SD group than in control group (P<0.01). Rats treated with low, middle and high dose of geniposide had shorter escape latency than those in SD group (P<0.01). The number of cross-platform was less in SD group than in control group, with statistical difference (P<0.01). Platform crossing frequencies were greater in rats treated with low, middle, and high dose of geniposide than those in SD group, and the number of cross-platform was higher in rats treated with high dose of geniposide than in those managed with low dose. Conclusions The learning and memory abilities are obviously impaired in SD rats, yet geniposide may produce certain effect on learning and memory, particularly, high dose of geniposide can significantly improve learning and memory in rats with sleep deprivation. |
