| Objective To investigate the effects of low-dose xanthine oxidase inhibitor on vascular endothelial function and inflammatory response in patients with type 2 DN with HUA. Methods Ninety-six patients with type 2 DN complicated with HUA admitted to the 967th hospital of P.L.A. from January 2018 to May 2019 were enrolled. The patients who met the criteria for admission were randomly divided into febuxostat group and allopurinol group, with 48 cases in each. The two groups of patients received diabetes education, and they were treated with oral hypoglycemic drugs or insulin to control blood sugar. The febuxostat group was treated with febuxostat for 24 weeks, and the allopurinol group was given allopurinol tablets. The levels of UA, FPG, HbA1c, TC, TG, LDL-C, HDL-C, BUN, Cr, UACR, Ccr, ALT, CRP, IL-6, ET-1 were observed before and after treatment in patients. Thecorrelation between UA level and CRP, IL-6, ET-1 levelswas assessed after 24 weeks of treatment. Results No patients fell off in either group. Before treatment, there was no significant difference in gender, age, duration of disease, and various biochemical indicators between the two groups (P>0.05). After 24 weeks of treatment, the levels of UA, FPG, HbA1c, TC, TG, LDL-C, BUN, Cr, UACR, CRP, IL-6, ET-1 were significantly lower than before(P<0.05), and the levels of Ccr and HDL-C were significantly higher(P<0.05). The difference between the levels of UA, BUN, Cr, UACR, Ccr, CRP, IL-6 and ET-1 in febuxostat group after treatment was statistically different from that in allopurinol group (P<0.05).The difference in the remaining indexes was not statistically significant between the two groups(P>0.05). UA level was positively correlated with CPR, IL-6 andET-1(P<0.05). Conclusions Low-dose xanthine oxidase inhibitors have significant effect on reducing blood uric acid levels in patients with type 2 DN complicated with HUA, which has a better effect on vascular endothelial function and inflammatory response. |
