| Objective By analyzing the differences of carbohydrate antigen-125(CA125), lactic dehydrogenase(LDH), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR) and preoperative systemic immune-inflammation index(SⅡ) between patients of uterine sarcoma to evaluate their diagnostic value. Methods A retrospective study was performed to analyze the clinical data of 37 patients with uterine sarcoma treated by surgery for the first time in the First Affiliated Hospital of USTC from January 2015 to August 2019. During the same period, 74 patients with uterine fibroids who underwent concurrent surgery were selected as the uterine fibroids group. The peripheral blood routine test results, CA125 and LDH values of all patients within 1 week before surgery were statistically analyzed, and the values of NLR, PLR and SⅡ were calculated. Uterine sarcoma and uterine fibroids were used as the dependent variables for discriminant analysis. Six indicators, including tumor maximum diameter, LDH, CA125, NLR, PLR and SⅡ, were selected and Fisher's criterion was used to establish discriminant functions and verify the effect. Results LDH, CA125, NLR and SⅡ in peripheral blood of uterine sarcoma group were significantly higher than those of the uterine fibroids group with statistical significance (P<0.05). However, PLR in uterine sarcoma group were both lower than that in hysteromyoma group with statistical significance (P<0.05). The results showed that the correct prediction rate for uterine fibroids using the above six clinical indicators was 83.2%, and the correct determination rate for uterine sarcomas was 67.4%. Conclusions The preoperative LDH, CA125, NLR, PLR and SⅡ have clinical value in the early diagnosis and differential diagnosis of uterine sarcoma. |
