| Objective To explore the correlation between levels of serum soluble growth stimulation expressed gene 2 (sST2), matrix metalloproteinase (MMP)-2 and MMP-9 and prognosis in patients with acute myocardial infarction (AMI) complicated with heart failure (HF). Methods A total of 149 patients with AMI who were hospitalized in the Third People’s Hospital of Hainan Province from May 2017 to May 2018 were selected. The related data of patients after admission were recorded. The serum levels of sST2, MMP-2 and MMP-9 were measured at admission. According to whether HF was concurrent during hospitalization, the patients were divided into HF group (n=54) and non-HF group (n=95). At 12 months follow-up after discharge, the patients with AMI and HF were divided into poor prognosis group (n=16) and good prognosis group (n=38) according to whether there was malignant heart failure or cardiogenic death. The levels of serum sST2, MMP-2 and MMP-9 were compared between HF group and non-HF group and between poor prognosis group and good prognosis group. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of sST2, MMP-2 and MMP-9 in the prognosis of patients with AMI complicated with HF. Results The levels of serum sST2, MMP-2 and MMP-9 in HF group were higher than those in non-HF group (P<0.05). The incidence rate of adverse events was 29.63% (16/54) in HF group, and the levels of serum sST2, MMP-2 and MMP-9 in patients with poor prognosis were higher than those in patients with good prognosis (P<0.05). Multivariate logistic regression analysis found that sST2, MMP-2 and MMP-9 were independent risk factors for the prognosis of patients with AMI complicated with HF (P<0.05). The values of area under the curve (AUC) of sST2, MMP-2 and MMP-9 in predicting the prognosis of AMI patients with HF were 0.888, 0.938 and 0.715 respectively. Conclusions The serum levels of sST2, MMP-2 and MMP-9 in patients with AMI and HF significantly increased, and high levels of serum sST2, MMP-2 and MMP-9 may indicate a poor prognosis, and sST2, MMP-2 and MMP-9 have a good predictive value in the prognosis of patients. |
