| Objective To investigate the effect of nifedipine combined with ritodrine hydrochloride on the outcome of threatened premature delivery. Methods A total of 94 expectant mothers with preterm birth admitted to the 71st Group Military Hospital of the PLA from March 2017 to September 2018 were selected as the study subjects. According to the random table method, they were divided into two groups, with 47 cases in control group and 47 cases in observation group. The control group was treated with ritodrine hydrochloride, while the observation group was treated with nifedipine on the basis of the control group. The therapeutic effects, prolonged pregnancy time and successful rate of fetal protection, changes of serum inflammatory factors before and after treatment, and maternal and infant outcomes were compared between the two groups. Results The total effective rate of pregnant women in observation group (95.74%) was higher than that in control group (76.60%)with statistically significant difference (P<0.05).The pregnant women inobservation group extended their gestation time for (21.74±3.42) d, and the success rate of fetal protection was (95.74%), both of which were better than those of control group,and the differences were statistically significant (P<0.05).Compared with those before treatment, serum IL-2 levels of pregnant women in two groups decreased after treatment, while IL-4 and IL-10 levels increased, with statistically significant differences (P<0.05).The difference in serum inflammatory factors before and after treatment in observation group was higher than that in control group, and the difference was statistically significant (P<0.05).There was no significant difference in birth asphyxia, low body mass index and perinatal mortality between the two groups (P>0.05).Conclusions Nifedipine combined with ritodrine hydrochloride has a good effect on threatened preterm pregnant women and good maternal and infant outcomes, which is worthy of clinical reference. |
